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Structure and dynamics of G protein-coupled receptor-bound ghrelin reveal the critical role of the octanoyl chain.
Ferré G, Louet M, Saurel O, Delort B, Czaplicki G, M'Kadmi C, Damian M, Renault P, Cantel S, Gavara L, Demange P, Marie J, Fehrentz JA, Floquet N, Milon A, Banères JL. Ferré G, et al. Among authors: fehrentz ja. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17525-17530. doi: 10.1073/pnas.1905105116. Epub 2019 Aug 15. Proc Natl Acad Sci U S A. 2019. PMID: 31416915 Free PMC article.
Recent developments in ghrelin receptor ligands.
Moulin A, Ryan J, Martinez J, Fehrentz JA. Moulin A, et al. Among authors: fehrentz ja. ChemMedChem. 2007 Sep;2(9):1242-59. doi: 10.1002/cmdc.200700015. ChemMedChem. 2007. PMID: 17520591 Review.
Toward potent ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure. 2. Synthesis and pharmacological in vitro and in vivo evaluations.
Moulin A, Demange L, Bergé G, Gagne D, Ryan J, Mousseaux D, Heitz A, Perrissoud D, Locatelli V, Torsello A, Galleyrand JC, Fehrentz JA, Martinez J. Moulin A, et al. Among authors: fehrentz ja. J Med Chem. 2007 Nov 15;50(23):5790-806. doi: 10.1021/jm0704550. Epub 2007 Oct 10. J Med Chem. 2007. PMID: 17927165
New trisubstituted 1,2,4-triazole derivatives as potent ghrelin receptor antagonists. 3. Synthesis and pharmacological in vitro and in vivo evaluations.
Moulin A, Demange L, Ryan J, Mousseaux D, Sanchez P, Bergé G, Gagne D, Perrissoud D, Locatelli V, Torsello A, Galleyrand JC, Fehrentz JA, Martinez J. Moulin A, et al. Among authors: fehrentz ja. J Med Chem. 2008 Feb 14;51(3):689-93. doi: 10.1021/jm701292s. Epub 2008 Jan 15. J Med Chem. 2008. PMID: 18193826
140 results