Jui NT - Search Results

1

Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design.

Mays SG, Flynn AR, Cornelison JL, Okafor CD, Wang H, Wang G, Huang X, Donaldson HN, Millings EJ, Polavarapu R, Moore DD, Calvert JW, Jui NT, Ortlund EA. Mays SG, et al. Among authors: jui nt. J Med Chem. 2019 Dec 26;62(24):11022-11034. doi: 10.1021/acs.jmedchem.9b00753. Epub 2019 Sep 6. J Med Chem. 2019. PMID: 31419141 Free PMC article.

2

Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists.

Mays SG, Okafor CD, Whitby RJ, Goswami D, Stec J, Flynn AR, Dugan MC, Jui NT, Griffin PR, Ortlund EA. Mays SG, et al. Among authors: jui nt. J Biol Chem. 2016 Dec 2;291(49):25281-25291. doi: 10.1074/jbc.M116.753541. Epub 2016 Sep 30. J Biol Chem. 2016. PMID: 27694446 Free PMC article.

3

A mild catalytic system for radical conjugate addition of nitrogen heterocycles.

Aycock RA, Wang H, Jui NT. Aycock RA, et al. Among authors: jui nt. Chem Sci. 2017 Apr 1;8(4):3121-3125. doi: 10.1039/c7sc00243b. Epub 2017 Feb 13. Chem Sci. 2017. PMID: 28507687 Free PMC article.

4

Development of Hybrid Phospholipid Mimics as Effective Agonists for Liver Receptor Homologue-1.

Flynn AR, Mays SG, Ortlund EA, Jui NT. Flynn AR, et al. Among authors: jui nt. ACS Med Chem Lett. 2018 Sep 4;9(10):1051-1056. doi: 10.1021/acsmedchemlett.8b00361. eCollection 2018 Oct 11. ACS Med Chem Lett. 2018. PMID: 30344916 Free PMC article.

5

Development of a Versatile and Sensitive Direct Ligand Binding Assay for Human NR5A Nuclear Receptors.

D'Agostino EH, Flynn AR, Cornelison JL, Mays SG, Patel A, Jui NT, Ortlund EA. D'Agostino EH, et al. Among authors: jui nt. ACS Med Chem Lett. 2019 Nov 21;11(3):365-370. doi: 10.1021/acsmedchemlett.9b00442. eCollection 2020 Mar 12. ACS Med Chem Lett. 2019. PMID: 32184971 Free PMC article.

6

Hydroarylation of Arenes via Reductive Radical-Polar Crossover.

Flynn AR, McDaniel KA, Hughes ME, Vogt DB, Jui NT. Flynn AR, et al. Among authors: jui nt. J Am Chem Soc. 2020 May 20;142(20):9163-9168. doi: 10.1021/jacs.0c03926. Epub 2020 May 11. J Am Chem Soc. 2020. PMID: 32379445 Free PMC article.

7

Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition.

Cornelison JL, Cato ML, Johnson AM, D'Agostino EH, Melchers D, Patel AB, Mays SG, Houtman R, Ortlund EA, Jui NT. Cornelison JL, et al. Among authors: jui nt. Bioorg Med Chem Lett. 2020 Aug 15;30(16):127293. doi: 10.1016/j.bmcl.2020.127293. Epub 2020 May 30. Bioorg Med Chem Lett. 2020. PMID: 32631515 Free PMC article.

8

A phospholipid mimetic targeting LRH-1 ameliorates colitis.

Mays SG, D'Agostino EH, Flynn AR, Huang X, Wang G, Liu X, Millings EJ, Okafor CD, Patel A, Cato ML, Cornelison JL, Melchers D, Houtman R, Moore DD, Calvert JW, Jui NT, Ortlund EA. Mays SG, et al. Among authors: jui nt. Cell Chem Biol. 2022 Jul 21;29(7):1174-1186.e7. doi: 10.1016/j.chembiol.2022.03.001. Epub 2022 Mar 21. Cell Chem Biol. 2022. PMID: 35316658 Free PMC article.

9

Differential Modulation of Nuclear Receptor LRH-1 through Targeting Buried and Surface Regions of the Binding Pocket.

Cato ML, Cornelison JL, Spurlin RM, Courouble VV, Patel AB, Flynn AR, Johnson AM, Okafor CD, Frank F, D'Agostino EH, Griffin PR, Jui NT, Ortlund EA. Cato ML, et al. Among authors: jui nt. J Med Chem. 2022 May 12;65(9):6888-6902. doi: 10.1021/acs.jmedchem.2c00235. Epub 2022 May 3. J Med Chem. 2022. PMID: 35503419 Free PMC article.

10

[No title available]

[No authors listed] [No authors listed] PMID: 35555641

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