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Allosteric modulation of β-cell M3 muscarinic acetylcholine receptors greatly improves glucose homeostasis in lean and obese mice.
Zhu L, Rossi M, Cohen A, Pham J, Zheng H, Dattaroy D, Mukaibo T, Melvin JE, Langel JL, Hattar S, Matschinsky FM, Appella DH, Doliba NM, Wess J. Zhu L, et al. Among authors: matschinsky fm. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18684-18690. doi: 10.1073/pnas.1904943116. Epub 2019 Aug 26. Proc Natl Acad Sci U S A. 2019. PMID: 31451647 Free PMC article.
Intra-islet glucagon signaling is critical for maintaining glucose homeostasis.
Zhu L, Dattaroy D, Pham J, Wang L, Barella LF, Cui Y, Wilkins KJ, Roth BL, Hochgeschwender U, Matschinsky FM, Kaestner KH, Doliba NM, Wess J. Zhu L, et al. Among authors: matschinsky fm. JCI Insight. 2019 Apr 23;5(10):e127994. doi: 10.1172/jci.insight.127994. JCI Insight. 2019. PMID: 31012868 Free PMC article.
β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions.
Zhu L, Almaça J, Dadi PK, Hong H, Sakamoto W, Rossi M, Lee RJ, Vierra NC, Lu H, Cui Y, McMillin SM, Perry NA, Gurevich VV, Lee A, Kuo B, Leapman RD, Matschinsky FM, Doliba NM, Urs NM, Caron MG, Jacobson DA, Caicedo A, Wess J. Zhu L, et al. Among authors: matschinsky fm. Nat Commun. 2017 Feb 1;8:14295. doi: 10.1038/ncomms14295. Nat Commun. 2017. PMID: 28145434 Free PMC article.
Restitution of defective glucose-stimulated insulin release of sulfonylurea type 1 receptor knockout mice by acetylcholine.
Doliba NM, Qin W, Vatamaniuk MZ, Li C, Zelent D, Najafi H, Buettger CW, Collins HW, Carr RD, Magnuson MA, Matschinsky FM. Doliba NM, et al. Among authors: matschinsky fm. Am J Physiol Endocrinol Metab. 2004 May;286(5):E834-43. doi: 10.1152/ajpendo.00292.2003. Epub 2004 Jan 21. Am J Physiol Endocrinol Metab. 2004. PMID: 14736703 Free article.
278 results