Huang SZ - Search Results

1

Isoliquiritigenin, an Orally Available Natural FLT3 Inhibitor from Licorice, Exhibits Selective Anti-Acute Myeloid Leukemia Efficacy In Vitro and In Vivo.

Cao ZX, Wen Y, He JL, Huang SZ, Gao F, Guo CJ, Liu QQ, Zheng SW, Gong DY, Li YZ, Zhang RQ, Chen JP, Peng C. Cao ZX, et al. Among authors: huang sz. Mol Pharmacol. 2019 Nov;96(5):589-599. doi: 10.1124/mol.119.116129. Epub 2019 Aug 28. Mol Pharmacol. 2019. PMID: 31462456

2

Drug Discovery against Psoriasis: Identification of a New Potent FMS-like Tyrosine Kinase 3 (FLT3) Inhibitor, 1-(4-((1H-Pyrazolo[3,4-d]pyrimidin-4-yl)oxy)-3-fluorophenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea, That Showed Potent Activity in a Psoriatic Animal Model.

Li GB, Ma S, Yang LL, Ji S, Fang Z, Zhang G, Wang LJ, Zhong JM, Xiong Y, Wang JH, Huang SZ, Li LL, Xiang R, Niu D, Chen YC, Yang SY. Li GB, et al. Among authors: huang sz. J Med Chem. 2016 Sep 22;59(18):8293-305. doi: 10.1021/acs.jmedchem.6b00604. Epub 2016 Sep 2. J Med Chem. 2016. PMID: 27535613

3

Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations.

Ji S, Ma S, Wang WJ, Huang SZ, Wang TQ, Xiang R, Hu YG, Chen Q, Li LL, Yang SY. Ji S, et al. Among authors: huang sz. Chem Biol Drug Des. 2017 Apr;89(4):585-598. doi: 10.1111/cbdd.12881. Epub 2016 Nov 10. Chem Biol Drug Des. 2017. PMID: 27714957

4

Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity.

Chen X, Sun W, Huang S, Zhang H, Lin G, Li H, Qiao J, Li L, Yang S. Chen X, et al. J Med Chem. 2020 Sep 24;63(18):10474-10495. doi: 10.1021/acs.jmedchem.0c01183. Epub 2020 Sep 9. J Med Chem. 2020. PMID: 32787077

5

From Lead to Drug Candidate: Optimization of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Derivatives as Agents for the Treatment of Triple Negative Breast Cancer.

Zhang CH, Chen K, Jiao Y, Li LL, Li YP, Zhang RJ, Zheng MW, Zhong L, Huang SZ, Song CL, Lin WT, Yang J, Xiang R, Peng B, Han JH, Lu GW, Wei YQ, Yang SY. Zhang CH, et al. Among authors: huang sz. J Med Chem. 2016 Nov 10;59(21):9788-9805. doi: 10.1021/acs.jmedchem.6b00943. Epub 2016 Oct 26. J Med Chem. 2016. PMID: 27739679

6

Discovery of New SIRT2 Inhibitors by Utilizing a Consensus Docking/Scoring Strategy and Structure-Activity Relationship Analysis.

Huang S, Song C, Wang X, Zhang G, Wang Y, Jiang X, Sun Q, Huang L, Xiang R, Hu Y, Li L, Yang S. Huang S, et al. J Chem Inf Model. 2017 Apr 24;57(4):669-679. doi: 10.1021/acs.jcim.6b00714. Epub 2017 Mar 28. J Chem Inf Model. 2017. PMID: 28301150

7

Structural optimization and structure-activity relationship studies of N-phenyl-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazin-4-amine derivatives as a new class of inhibitors of RET and its drug resistance mutants.

Yang J, Chen K, Zhang G, Yang QY, Li YS, Huang SZ, Wang YL, Yang W, Jiang XJ, Yan HX, Zhu JQ, Xiang R, Luo YF, Li WM, Wei YQ, Li LL, Yang SY. Yang J, et al. Among authors: huang sz. Eur J Med Chem. 2018 Jan 1;143:1148-1164. doi: 10.1016/j.ejmech.2017.09.018. Epub 2017 Sep 15. Eur J Med Chem. 2018. PMID: 29133048

8

Discovery of KDM5A inhibitors: Homology modeling, virtual screening and structure-activity relationship analysis.

Wu X, Fang Z, Yang B, Zhong L, Yang Q, Zhang C, Huang S, Xiang R, Suzuki T, Li LL, Yang SY. Wu X, et al. Bioorg Med Chem Lett. 2016 May 1;26(9):2284-8. doi: 10.1016/j.bmcl.2016.03.048. Epub 2016 Mar 14. Bioorg Med Chem Lett. 2016. PMID: 27020306

9

Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model.

Yang W, Liu X, Song C, Ji S, Yang J, Liu Y, You J, Zhang J, Huang S, Cheng W, Shao Z, Li L, Yang S. Yang W, et al. Eur J Med Chem. 2021 Jan 1;209:112842. doi: 10.1016/j.ejmech.2020.112842. Epub 2020 Sep 18. Eur J Med Chem. 2021. PMID: 33065375

10

Discovery of 5-(4-methylpiperazin-1-yl)-2-nitroaniline derivatives as a new class of SIRT6 inhibitors.

Sun W, Chen X, Huang S, Li W, Tian C, Yang S, Li L. Sun W, et al. Bioorg Med Chem Lett. 2020 Aug 15;30(16):127215. doi: 10.1016/j.bmcl.2020.127215. Epub 2020 Apr 25. Bioorg Med Chem Lett. 2020. PMID: 32631504

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