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Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukemia cells from oxidative stress.
Burt R, Dey A, Aref S, Aguiar M, Akarca A, Bailey K, Day W, Hooper S, Kirkwood A, Kirschner K, Lee SW, Lo Celso C, Manji J, Mansour MR, Marafioti T, Mitchell RJ, Muirhead RC, Cheuk Yan Ng K, Pospori C, Puccio I, Zuborne-Alapi K, Sahai E, Fielding AK. Burt R, et al. Among authors: kirschner k. Blood. 2019 Oct 24;134(17):1415-1429. doi: 10.1182/blood.2019001398. Blood. 2019. PMID: 31501154 Free PMC article.
Mitochondrial dsRNA from B-ALL cells stimulates mesenchymal stromal cells to become cancer-associated fibroblasts.
Burt RJ, Dey A, Akarca A, Allen H, Amerikanou R, Atkinson S, Auty D, Chatzigerou J, Cutler E, Guerra-Assuncao JA, Kirschner K, Kumari R, Manji J, Marafioti T, Ward J, Fielding AK. Burt RJ, et al. Among authors: kirschner k. Blood Adv. 2024 Nov 12;8(21):5696-5709. doi: 10.1182/bloodadvances.2023012077. Blood Adv. 2024. PMID: 39226456 Free PMC article.
BRD4-mediated repression of p53 is a target for combination therapy in AML.
Latif AL, Newcombe A, Li S, Gilroy K, Robertson NA, Lei X, Stewart HJS, Cole J, Terradas MT, Rishi L, McGarry L, McKeeve C, Reid C, Clark W, Campos J, Kirschner K, Davis A, Lopez J, Sakamaki JI, Morton JP, Ryan KM, Tait SWG, Abraham SA, Holyoake T, Higgins B, Huang X, Blyth K, Copland M, Chevassut TJT, Keeshan K, Adams PD. Latif AL, et al. Among authors: kirschner k. Nat Commun. 2021 Jan 11;12(1):241. doi: 10.1038/s41467-020-20378-8. Nat Commun. 2021. PMID: 33431824 Free PMC article.
Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53.
Kirschner K, Samarajiwa SA, Cairns JM, Menon S, Pérez-Mancera PA, Tomimatsu K, Bermejo-Rodriguez C, Ito Y, Chandra T, Narita M, Lyons SK, Lynch AG, Kimura H, Ohbayashi T, Tavaré S, Narita M. Kirschner K, et al. PLoS Genet. 2015 Mar 19;11(3):e1005053. doi: 10.1371/journal.pgen.1005053. eCollection 2015 Mar. PLoS Genet. 2015. PMID: 25790137 Free PMC article.
324 results