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Bortezomib blocks the catabolic process of autophagy via a cathepsin-dependent mechanism, affects endoplasmic reticulum stress and induces caspase-dependent cell death in antiestrogen-sensitive and resistant ER+ breast cancer cells.
Periyasamy-Thandavan S, Jackson WH, Samaddar JS, Erickson B, Barrett JR, Raney L, Gopal E, Ganapathy V, Hill WD, Bhalla KN, Schoenlein PV. Periyasamy-Thandavan S, et al. Autophagy. 2010 Jan;6(1):19-35. doi: 10.4161/auto.6.1.10323. Autophagy. 2010. PMID: 20110775
Rapamycin up-regulation of autophagy reduces infarct size and improves outcomes in both permanent MCAL, and embolic MCAO, murine models of stroke.
Buckley KM, Hess DL, Sazonova IY, Periyasamy-Thandavan S, Barrett JR, Kirks R, Grace H, Kondrikova G, Johnson MH, Hess DC, Schoenlein PV, Hoda MN, Hill WD. Buckley KM, et al. Exp Transl Stroke Med. 2014 Jun 21;6:8. doi: 10.1186/2040-7378-6-8. eCollection 2014. Exp Transl Stroke Med. 2014. PMID: 24991402 Free PMC article.
Caloric restriction and the adipokine leptin alter the SDF-1 signaling axis in bone marrow and in bone marrow derived mesenchymal stem cells.
Periyasamy-Thandavan S, Herberg S, Arounleut P, Upadhyay S, Dukes A, Davis C, Johnson M, McGee-Lawrence M, Hamrick MW, Isales CM, Hill WD. Periyasamy-Thandavan S, et al. Mol Cell Endocrinol. 2015 Jul 15;410:64-72. doi: 10.1016/j.mce.2015.03.001. Epub 2015 Mar 14. Mol Cell Endocrinol. 2015. PMID: 25779533 Free PMC article.
23 results