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Page 1
The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Pang SS, Bayly-Jones C, Radjainia M, Spicer BA, Law RHP, Hodel AW, Parsons ES, Ekkel SM, Conroy PJ, Ramm G, Venugopal H, Bird PI, Hoogenboom BW, Voskoboinik I, Gambin Y, Sierecki E, Dunstone MA, Whisstock JC. Pang SS, et al. Among authors: hodel aw. Nat Commun. 2019 Sep 19;10(1):4288. doi: 10.1038/s41467-019-12279-2. Nat Commun. 2019. PMID: 31537793 Free PMC article.
Real-time visualization of perforin nanopore assembly.
Leung C, Hodel AW, Brennan AJ, Lukoyanova N, Tran S, House CM, Kondos SC, Whisstock JC, Dunstone MA, Trapani JA, Voskoboinik I, Saibil HR, Hoogenboom BW. Leung C, et al. Among authors: hodel aw. Nat Nanotechnol. 2017 May;12(5):467-473. doi: 10.1038/nnano.2016.303. Epub 2017 Feb 6. Nat Nanotechnol. 2017. PMID: 28166206
Single-molecule kinetics of pore assembly by the membrane attack complex.
Parsons ES, Stanley GJ, Pyne ALB, Hodel AW, Nievergelt AP, Menny A, Yon AR, Rowley A, Richter RP, Fantner GE, Bubeck D, Hoogenboom BW. Parsons ES, et al. Among authors: hodel aw. Nat Commun. 2019 May 6;10(1):2066. doi: 10.1038/s41467-019-10058-7. Nat Commun. 2019. PMID: 31061395 Free PMC article.
Lipid order and charge protect killer T cells from accidental death.
Rudd-Schmidt JA, Hodel AW, Noori T, Lopez JA, Cho HJ, Verschoor S, Ciccone A, Trapani JA, Hoogenboom BW, Voskoboinik I. Rudd-Schmidt JA, et al. Among authors: hodel aw. Nat Commun. 2019 Nov 27;10(1):5396. doi: 10.1038/s41467-019-13385-x. Nat Commun. 2019. PMID: 31776337 Free PMC article.
AFM imaging of pore forming proteins.
Hodel AW, Hammond K, Hoogenboom BW. Hodel AW, et al. Methods Enzymol. 2021;649:149-188. doi: 10.1016/bs.mie.2021.01.002. Epub 2021 Feb 10. Methods Enzymol. 2021. PMID: 33712186
Lipid specificity of the immune effector perforin.
Hodel AW, Rudd-Schmidt JA, Trapani JA, Voskoboinik I, Hoogenboom BW. Hodel AW, et al. Faraday Discuss. 2021 Dec 24;232(0):236-255. doi: 10.1039/d0fd00043d. Faraday Discuss. 2021. PMID: 34545865 Free PMC article.
Pharmacologic inhibition of dipeptidyl peptidase 1 (cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells.
Sutton VR, Watt SV, Akhlaghi H, Cipolla DC, Chen KJ, LaSala D, McDonald PP, Beavis PA, Munoz I, Hodel AW, Noori T, Voskoboinik I, Trapani JA. Sutton VR, et al. Among authors: hodel aw. Front Pharmacol. 2024 Jul 3;15:1396710. doi: 10.3389/fphar.2024.1396710. eCollection 2024. Front Pharmacol. 2024. PMID: 39021839 Free PMC article.
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