Heinen CD - Search Results

1

Enhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways.

Taghbalout A, Du M, Jillette N, Rosikiewicz W, Rath A, Heinen CD, Li S, Cheng AW. Taghbalout A, et al. Among authors: heinen cd. Nat Commun. 2019 Sep 20;10(1):4296. doi: 10.1038/s41467-019-12339-7. Nat Commun. 2019. PMID: 31541098 Free PMC article.

2

Functional interrogation of Lynch syndrome-associated MSH2 missense variants via CRISPR-Cas9 gene editing in human embryonic stem cells.

Rath A, Mishra A, Ferreira VD, Hu C, Omerza G, Kelly K, Hesse A, Reddi HV, Grady JP, Heinen CD. Rath A, et al. Among authors: heinen cd. Hum Mutat. 2019 Nov;40(11):2044-2056. doi: 10.1002/humu.23848. Epub 2019 Aug 17. Hum Mutat. 2019. PMID: 31237724 Free PMC article.

3

A calibrated cell-based functional assay to aid classification of MLH1 DNA mismatch repair gene variants.

Rath A, Radecki AA, Rahman K, Gilmore RB, Hudson JR, Cenci M, Tavtigian SV, Grady JP, Heinen CD. Rath A, et al. Among authors: heinen cd. Hum Mutat. 2022 Dec;43(12):2295-2307. doi: 10.1002/humu.24462. Epub 2022 Sep 12. Hum Mutat. 2022. PMID: 36054288 Free PMC article.

4

The mismatch repair-dependent DNA damage response: Mechanisms and implications.

Gupta D, Heinen CD. Gupta D, et al. Among authors: heinen cd. DNA Repair (Amst). 2019 Jun;78:60-69. doi: 10.1016/j.dnarep.2019.03.009. Epub 2019 Apr 1. DNA Repair (Amst). 2019. PMID: 30959407 Review.

5

Translating mismatch repair mechanism into cancer care.

Heinen CD. Heinen CD. Curr Drug Targets. 2014 Jan;15(1):53-64. doi: 10.2174/1389450114666140106100128. Curr Drug Targets. 2014. PMID: 24387335

6

Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database.

Thompson BA, Spurdle AB, Plazzer JP, Greenblatt MS, Akagi K, Al-Mulla F, Bapat B, Bernstein I, Capellá G, den Dunnen JT, du Sart D, Fabre A, Farrell MP, Farrington SM, Frayling IM, Frebourg T, Goldgar DE, Heinen CD, Holinski-Feder E, Kohonen-Corish M, Robinson KL, Leung SY, Martins A, Moller P, Morak M, Nystrom M, Peltomaki P, Pineda M, Qi M, Ramesar R, Rasmussen LJ, Royer-Pokora B, Scott RJ, Sijmons R, Tavtigian SV, Tops CM, Weber T, Wijnen J, Woods MO, Macrae F, Genuardi M. Thompson BA, et al. Among authors: heinen cd. Nat Genet. 2014 Feb;46(2):107-115. doi: 10.1038/ng.2854. Epub 2013 Dec 22. Nat Genet. 2014. PMID: 24362816 Free PMC article.

7

Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage.

Mastrocola AS, Heinen CD. Mastrocola AS, et al. Among authors: heinen cd. DNA Repair (Amst). 2010 Feb 4;9(2):120-33. doi: 10.1016/j.dnarep.2009.11.003. Epub 2009 Dec 8. DNA Repair (Amst). 2010. PMID: 20004149 Free PMC article.

8

Milestones of Lynch syndrome: 1895-2015.

Lynch HT, Snyder CL, Shaw TG, Heinen CD, Hitchins MP. Lynch HT, et al. Among authors: heinen cd. Nat Rev Cancer. 2015 Mar;15(3):181-94. doi: 10.1038/nrc3878. Epub 2015 Feb 12. Nat Rev Cancer. 2015. PMID: 25673086 Review.

9

Loss of DNA mismatch repair imparts a selective advantage in planarian adult stem cells.

Hollenbach JP, Resch AM, Palakodeti D, Graveley BR, Heinen CD. Hollenbach JP, et al. Among authors: heinen cd. PLoS One. 2011;6(7):e21808. doi: 10.1371/journal.pone.0021808. Epub 2011 Jul 1. PLoS One. 2011. PMID: 21747960 Free PMC article.

10

C-terminal UBA domains protect ubiquitin receptors by preventing initiation of protein degradation.

Heinen C, Acs K, Hoogstraten D, Dantuma NP. Heinen C, et al. Nat Commun. 2011 Feb 8;2:191. doi: 10.1038/ncomms1179. Nat Commun. 2011. PMID: 21304520 Free PMC article.

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