Sameshima T - Search Results

1

Identification of 2,6-Disubstituted 3H-Imidazo[4,5-b]pyridines as Therapeutic Agents for Dysferlinopathies through Phenotypic Screening on Patient-Derived Induced Pluripotent Stem Cells.

Takada H, Kaieda A, Tawada M, Nagino T, Sasa K, Oikawa T, Oki A, Sameshima T, Miyamoto K, Miyamoto M, Kokubu Y, Tozawa R, Sakurai H, Saito B. Takada H, et al. Among authors: sameshima t. J Med Chem. 2019 Oct 24;62(20):9175-9187. doi: 10.1021/acs.jmedchem.9b01100. Epub 2019 Oct 7. J Med Chem. 2019. PMID: 31550153

2

Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.

Tanaka Y, Aikawa K, Nishida G, Homma M, Sogabe S, Igaki S, Hayano Y, Sameshima T, Miyahisa I, Kawamoto T, Tawada M, Imai Y, Inazuka M, Cho N, Imaeda Y, Ishikawa T. Tanaka Y, et al. Among authors: sameshima t. J Med Chem. 2013 Dec 12;56(23):9635-45. doi: 10.1021/jm401170c. Epub 2013 Dec 2. J Med Chem. 2013. PMID: 24215352

3

Discovery of 3-Benzyl-1-( trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors.

Ito M, Tanaka T, Toita A, Uchiyama N, Kokubo H, Morishita N, Klein MG, Zou H, Murakami M, Kondo M, Sameshima T, Araki S, Endo S, Kawamoto T, Morin GB, Aparicio SA, Nakanishi A, Maezaki H, Imaeda Y. Ito M, et al. Among authors: sameshima t. J Med Chem. 2018 Sep 13;61(17):7710-7728. doi: 10.1021/acs.jmedchem.8b00683. Epub 2018 Aug 20. J Med Chem. 2018. PMID: 30067358

4

Small-Scale Panel Comprising Diverse Gene Family Targets To Evaluate Compound Promiscuity.

Sameshima T, Yukawa T, Hirozane Y, Yoshikawa M, Katoh T, Hara H, Yogo T, Miyahisa I, Okuda T, Miyamoto M, Naven R. Sameshima T, et al. Chem Res Toxicol. 2020 Jan 21;33(1):154-161. doi: 10.1021/acs.chemrestox.9b00128. Epub 2019 Sep 6. Chem Res Toxicol. 2020. PMID: 31461269

5

A simple and widely applicable hit validation strategy for protein-protein interaction inhibitors based on a quantitative ligand displacement assay.

Sameshima T, Miyahisa I, Homma M, Aikawa K, Hixon MS, Matsui J. Sameshima T, et al. Bioorg Med Chem Lett. 2014 Dec 15;24(24):5836-5839. doi: 10.1016/j.bmcl.2014.09.073. Epub 2014 Oct 2. Bioorg Med Chem Lett. 2014. PMID: 25452002

6

Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging.

Niida A, Sasaki S, Yonemori K, Sameshima T, Yaguchi M, Asami T, Sakamoto K, Kamaura M. Niida A, et al. Among authors: sameshima t. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2757-2761. doi: 10.1016/j.bmcl.2017.04.063. Epub 2017 Apr 21. Bioorg Med Chem Lett. 2017. PMID: 28457754

7

Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d.

Sogabe S, Kamada Y, Miwa M, Niida A, Sameshima T, Kamaura M, Yonemori K, Sasaki S, Sakamoto JI, Sakamoto K. Sogabe S, et al. Among authors: sameshima t. ACS Med Chem Lett. 2017 May 10;8(7):732-736. doi: 10.1021/acsmedchemlett.7b00128. eCollection 2017 Jul 13. ACS Med Chem Lett. 2017. PMID: 28740607 Free PMC article.

8

Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode.

Fujimoto J, Kurasawa O, Takagi T, Liu X, Banno H, Kojima T, Asano Y, Nakamura A, Nambu T, Hata A, Ishii T, Sameshima T, Debori Y, Miyamoto M, Klein MG, Tjhen R, Sang BC, Levin I, Lane SW, Snell GP, Li K, Kefala G, Hoffman ID, Ding SC, Cary DR, Mizojiri R. Fujimoto J, et al. Among authors: sameshima t. ACS Med Chem Lett. 2019 Sep 19;10(10):1498-1503. doi: 10.1021/acsmedchemlett.9b00400. eCollection 2019 Oct 10. ACS Med Chem Lett. 2019. PMID: 31620240 Free PMC article.

9

Structure-based rational design of staurosporine-based fluorescent probe with broad-ranging kinase affinity for kinase panel application.

Hirozane Y, Toyofuku M, Yogo T, Tanaka Y, Sameshima T, Miyahisa I, Yoshikawa M. Hirozane Y, et al. Among authors: sameshima t. Bioorg Med Chem Lett. 2019 Nov 1;29(21):126641. doi: 10.1016/j.bmcl.2019.126641. Epub 2019 Sep 7. Bioorg Med Chem Lett. 2019. PMID: 31526603

10

Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation.

Shimokawa K, Shibata N, Sameshima T, Miyamoto N, Ujikawa O, Nara H, Ohoka N, Hattori T, Cho N, Naito M. Shimokawa K, et al. Among authors: sameshima t. ACS Med Chem Lett. 2017 Sep 14;8(10):1042-1047. doi: 10.1021/acsmedchemlett.7b00247. eCollection 2017 Oct 12. ACS Med Chem Lett. 2017. PMID: 29057048 Free PMC article.

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