Cushman M - Search Results

1

Topoisomerase IB poisons induce histone H2A phosphorylation as a response to DNA damage in Leishmania infantum.

Gutiérrez-Corbo C, Álvarez-Velilla R, Reguera RM, García-Estrada C, Cushman M, Balaña-Fouce R, Pérez-Pertejo Y. Gutiérrez-Corbo C, et al. Among authors: cushman m. Int J Parasitol Drugs Drug Resist. 2019 Dec;11:39-48. doi: 10.1016/j.ijpddr.2019.09.005. Epub 2019 Sep 20. Int J Parasitol Drugs Drug Resist. 2019. PMID: 31563118 Free PMC article.

2

Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis.

Ioanoviciu A, Antony S, Pommier Y, Staker BL, Stewart L, Cushman M. Ioanoviciu A, et al. Among authors: cushman m. J Med Chem. 2005 Jul 28;48(15):4803-14. doi: 10.1021/jm050076b. J Med Chem. 2005. PMID: 16033260

3

Dibenzo[c,h][1,5]naphthyridinediones as topoisomerase I inhibitors: design, synthesis, and biological evaluation.

Kiselev E, Empey N, Agama K, Pommier Y, Cushman M. Kiselev E, et al. Among authors: cushman m. J Org Chem. 2012 Jun 1;77(11):5167-72. doi: 10.1021/jo3006039. Epub 2012 May 15. J Org Chem. 2012. PMID: 22587603 Free PMC article.

4

Indotecan (LMP400) and AM13-55: two novel indenoisoquinolines show potential for treating visceral leishmaniasis.

Balaña-Fouce R, Prada CF, Requena JM, Cushman M, Pommier Y, Álvarez-Velilla R, Escudero-Martínez JM, Calvo-Álvarez E, Pérez-Pertejo Y, Reguera RM. Balaña-Fouce R, et al. Among authors: cushman m. Antimicrob Agents Chemother. 2012 Oct;56(10):5264-70. doi: 10.1128/AAC.00499-12. Epub 2012 Jul 30. Antimicrob Agents Chemother. 2012. PMID: 22850521 Free PMC article.

5

Synthesis and biological evaluation of new fluorinated and chlorinated indenoisoquinoline topoisomerase I poisons.

Beck DE, Lv W, Abdelmalak M, Plescia CB, Agama K, Marchand C, Pommier Y, Cushman M. Beck DE, et al. Among authors: cushman m. Bioorg Med Chem. 2016 Apr 1;24(7):1469-79. doi: 10.1016/j.bmc.2016.02.015. Epub 2016 Feb 9. Bioorg Med Chem. 2016. PMID: 26906474 Free PMC article.

6

Investigation of the Structure-Activity Relationships of Aza-A-Ring Indenoisoquinoline Topoisomerase I Poisons.

Beck DE, Reddy PV, Lv W, Abdelmalak M, Tender GS, Lopez S, Agama K, Marchand C, Pommier Y, Cushman M. Beck DE, et al. Among authors: cushman m. J Med Chem. 2016 Apr 28;59(8):3840-53. doi: 10.1021/acs.jmedchem.6b00003. Epub 2016 Apr 12. J Med Chem. 2016. PMID: 27070999 Free PMC article.

7

Antiparasitic effect of synthetic aromathecins on Leishmania infantum.

Reguera RM, Álvarez-Velilla R, Domínguez-Asenjo B, Gutiérrez-Corbo C, Balaña-Fouce R, Cushman M, Pérez-Pertejo Y. Reguera RM, et al. Among authors: cushman m. BMC Vet Res. 2019 Nov 9;15(1):405. doi: 10.1186/s12917-019-2153-9. BMC Vet Res. 2019. PMID: 31706354 Free PMC article.

8

Design and Synthesis of Indenoisoquinolines Targeting Topoisomerase I and Other Biological Macromolecules for Cancer Chemotherapy.

Cushman M. Cushman M. J Med Chem. 2021 Dec 23;64(24):17572-17600. doi: 10.1021/acs.jmedchem.1c01491. Epub 2021 Dec 8. J Med Chem. 2021. PMID: 34879200 Review.

9

Synthesis of cytotoxic indenoisoquinoline topoisomerase I poisons.

Strumberg D, Pommier Y, Paull K, Jayaraman M, Nagafuji P, Cushman M. Strumberg D, et al. Among authors: cushman m. J Med Chem. 1999 Feb 11;42(3):446-57. doi: 10.1021/jm9803323. J Med Chem. 1999. PMID: 9986716

10

Synthesis of new indeno[1,2-c]isoquinolines: cytotoxic non-camptothecin topoisomerase I inhibitors.

Cushman M, Jayaraman M, Vroman JA, Fukunaga AK, Fox BM, Kohlhagen G, Strumberg D, Pommier Y. Cushman M, et al. J Med Chem. 2000 Oct 5;43(20):3688-98. doi: 10.1021/jm000029d. J Med Chem. 2000. PMID: 11020283

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