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Phenylephrine-induced cardiomyocyte injury is triggered by superoxide generation through uncoupled endothelial nitric-oxide synthase and ameliorated by 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxyindazole (DY-9836), a novel calmodulin antagonist.
Lu YM, Han F, Shioda N, Moriguchi S, Shirasaki Y, Qin ZH, Fukunaga K. Lu YM, et al. Mol Pharmacol. 2009 Jan;75(1):101-12. doi: 10.1124/mol.108.050716. Epub 2008 Oct 24. Mol Pharmacol. 2009. PMID: 18952768
Inhibition of dystrophin breakdown and endothelial nitric-oxide synthase uncoupling accounts for cytoprotection by 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e) in left ventricular hypertrophied Mice.
Han F, Lu YM, Hasegawa H, Kanai H, Hachimura E, Shirasaki Y, Fukunaga K. Han F, et al. Among authors: lu ym. J Pharmacol Exp Ther. 2010 Feb;332(2):421-8. doi: 10.1124/jpet.109.161646. Epub 2009 Nov 4. J Pharmacol Exp Ther. 2010. PMID: 19889795
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