Bigger BW - Search Results

1

Post-transplant laronidase augmentation for children with Hurler syndrome: biochemical outcomes.

Lund TC, Miller WP, Liao AY, Tolar J, Shanley R, Pasquali M, Sando N, Bigger BW, Polgreen LE, Orchard PJ. Lund TC, et al. Among authors: bigger bw. Sci Rep. 2019 Oct 1;9(1):14105. doi: 10.1038/s41598-019-50595-1. Sci Rep. 2019. PMID: 31575939 Free PMC article. Clinical Trial.

2

Optimised protocols to generate high titre lentiviral vectors using a novel transfection agent enabling extended HEK293T culture following transient transfection and suspension culture.

Suleman S, Fawaz S, Roberts T, Ellison S, Bigger B, Themis M. Suleman S, et al. J Virol Methods. 2024 Apr;325:114884. doi: 10.1016/j.jviromet.2024.114884. Epub 2024 Jan 11. J Virol Methods. 2024. PMID: 38218417 Free article.

3

An Innovative Tool for Evidence-Based, Personalized Treatment Trials in Mucopolysaccharidosis.

Wiesinger AM, Bigger B, Giugliani R, Lampe C, Scarpa M, Moser T, Kampmann C, Zimmermann G, Lagler FB. Wiesinger AM, et al. Pharmaceutics. 2023 May 22;15(5):1565. doi: 10.3390/pharmaceutics15051565. Pharmaceutics. 2023. Retraction in: Pharmaceutics. 2023 Nov 07;15(11):2596. doi: 10.3390/pharmaceutics15112596 PMID: 37242808 Free PMC article. Retracted.

4

Fusion of Rabies Virus Glycoprotein or gh625 to Iduronate-2-Sulfatase for the Treatment of Mucopolysaccharidosis Type II.

Wood SR, Chaudrhy A, Ellison S, Searle R, Burgod C, Tehseen G, Forte G, O'Leary C, Gleitz H, Liao A, Cook J, Holley R, Bigger BW. Wood SR, et al. Among authors: bigger bw. Hum Gene Ther. 2024 Apr;35(7-8):232-242. doi: 10.1089/hum.2023.025. Epub 2023 Jul 7. Hum Gene Ther. 2024. PMID: 37212263

5

Intraparenchymal convection enhanced delivery of AAV in sheep to treat Mucopolysaccharidosis IIIC.

O'Leary C, Forte G, Mitchell NL, Youshani AS, Dyer A, Wellby MP, Russell KN, Murray SJ, Jolinon N, Jones SA, Stacey K, Davis DM, Henckaerts E, Palmer DN, Kamaly-Asl I, Bigger BW. O'Leary C, et al. Among authors: bigger bw. J Transl Med. 2023 Jul 5;21(1):437. doi: 10.1186/s12967-023-04208-1. J Transl Med. 2023. PMID: 37407981 Free PMC article.

6

Phenotypic characterisation of the Mucopolysaccharidosis Type I (MPSI) Idua-W392X mouse model reveals increased anxiety-related traits in female mice.

Andreou T, Ishikawa-Learmonth Y, Bigger BW. Andreou T, et al. Among authors: bigger bw. Mol Genet Metab. 2023 Aug;139(4):107651. doi: 10.1016/j.ymgme.2023.107651. Epub 2023 Jul 13. Mol Genet Metab. 2023. PMID: 37473537 Free article.

7

Myeloid/Microglial driven autologous hematopoietic stem cell gene therapy corrects a neuronopathic lysosomal disease.

Sergijenko A, Langford-Smith A, Liao AY, Pickford CE, McDermott J, Nowinski G, Langford-Smith KJ, Merry CL, Jones SA, Wraith JE, Wynn RF, Wilkinson FL, Bigger BW. Sergijenko A, et al. Among authors: bigger bw. Mol Ther. 2013 Oct;21(10):1938-49. doi: 10.1038/mt.2013.141. Epub 2013 Jun 7. Mol Ther. 2013. PMID: 23748415 Free PMC article.

8

Enzyme replacement therapy prior to haematopoietic stem cell transplantation in Mucopolysaccharidosis Type I: 10 year combined experience of 2 centres.

Ghosh A, Miller W, Orchard PJ, Jones SA, Mercer J, Church HJ, Tylee K, Lund T, Bigger BW, Tolar J, Wynn RF. Ghosh A, et al. Among authors: bigger bw. Mol Genet Metab. 2016 Mar;117(3):373-7. doi: 10.1016/j.ymgme.2016.01.011. Epub 2016 Jan 27. Mol Genet Metab. 2016. PMID: 26832957 Free PMC article.

9

Brain-targeted stem cell gene therapy corrects mucopolysaccharidosis type II via multiple mechanisms.

Gleitz HF, Liao AY, Cook JR, Rowlston SF, Forte GM, D'Souza Z, O'Leary C, Holley RJ, Bigger BW. Gleitz HF, et al. Among authors: bigger bw. EMBO Mol Med. 2018 Jul;10(7):e8730. doi: 10.15252/emmm.201708730. EMBO Mol Med. 2018. PMID: 29884617 Free PMC article.

10

Systemic immune challenge exacerbates neurodegeneration in a model of neurological lysosomal disease.

Mandolfo O, Parker H, Aguado È, Ishikawa Learmonth Y, Liao AY, O'Leary C, Ellison S, Forte G, Taylor J, Wood S, Searle R, Holley RJ, Boutin H, Bigger BW. Mandolfo O, et al. Among authors: bigger bw. EMBO Mol Med. 2024 Jul;16(7):1579-1602. doi: 10.1038/s44321-024-00092-4. Epub 2024 Jun 18. EMBO Mol Med. 2024. PMID: 38890537 Free PMC article.

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