Park J - Search Results

1

Chirality-Driven Mode of Binding of α-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).

Feng Y, Park J, Li SG, Boutin R, Viereck P, Schilling MA, Berghuis AM, Tsantrizos YS. Feng Y, et al. Among authors: park j. J Med Chem. 2019 Nov 14;62(21):9691-9702. doi: 10.1021/acs.jmedchem.9b01104. Epub 2019 Oct 16. J Med Chem. 2019. PMID: 31577901

2

Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells.

Lin YS, Park J, De Schutter JW, Huang XF, Berghuis AM, Sebag M, Tsantrizos YS. Lin YS, et al. Among authors: park j. J Med Chem. 2012 Apr 12;55(7):3201-15. doi: 10.1021/jm201657x. Epub 2012 Mar 19. J Med Chem. 2012. PMID: 22390415

3

Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure.

Park J, Lin YS, De Schutter JW, Tsantrizos YS, Berghuis AM. Park J, et al. BMC Struct Biol. 2012 Dec 12;12:32. doi: 10.1186/1472-6807-12-32. BMC Struct Biol. 2012. PMID: 23234314 Free PMC article.

4

Thienopyrimidine bisphosphonate (ThPBP) inhibitors of the human farnesyl pyrophosphate synthase: optimization and characterization of the mode of inhibition.

Leung CY, Park J, De Schutter JW, Sebag M, Berghuis AM, Tsantrizos YS. Leung CY, et al. Among authors: park j. J Med Chem. 2013 Oct 24;56(20):7939-50. doi: 10.1021/jm400946f. Epub 2013 Oct 3. J Med Chem. 2013. PMID: 23998921

5

Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate.

Park J, Lin YS, Tsantrizos YS, Berghuis AM. Park J, et al. Acta Crystallogr F Struct Biol Commun. 2014 Mar;70(Pt 3):299-304. doi: 10.1107/S2053230X14002106. Epub 2014 Feb 19. Acta Crystallogr F Struct Biol Commun. 2014. PMID: 24598914 Free PMC article.

6

Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases.

De Schutter JW, Park J, Leung CY, Gormley P, Lin YS, Hu Z, Berghuis AM, Poirier J, Tsantrizos YS. De Schutter JW, et al. Among authors: park j. J Med Chem. 2014 Jul 10;57(13):5764-76. doi: 10.1021/jm500629e. Epub 2014 Jun 23. J Med Chem. 2014. PMID: 24911527

7

Human isoprenoid synthase enzymes as therapeutic targets.

Park J, Matralis AN, Berghuis AM, Tsantrizos YS. Park J, et al. Front Chem. 2014 Jul 22;2:50. doi: 10.3389/fchem.2014.00050. eCollection 2014. Front Chem. 2014. PMID: 25101260 Free PMC article. Review.

8

Maintenance of native-like protein dynamics may not be required for engineering functional proteins.

Gobeil SMC, Clouthier CM, Park J, Gagné D, Berghuis AM, Doucet N, Pelletier JN. Gobeil SMC, et al. Among authors: park j. Chem Biol. 2014 Oct 23;21(10):1330-1340. doi: 10.1016/j.chembiol.2014.07.016. Epub 2014 Sep 4. Chem Biol. 2014. PMID: 25200606

9

Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase.

Gritzalis D, Park J, Chiu W, Cho H, Lin YS, De Schutter JW, Lacbay CM, Zielinski M, Berghuis AM, Tsantrizos YS. Gritzalis D, et al. Among authors: park j. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1117-23. doi: 10.1016/j.bmcl.2014.12.089. Epub 2015 Jan 13. Bioorg Med Chem Lett. 2015. PMID: 25630225

10

Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product.

Park J, Zielinski M, Magder A, Tsantrizos YS, Berghuis AM. Park J, et al. Nat Commun. 2017 Jan 18;8:14132. doi: 10.1038/ncomms14132. Nat Commun. 2017. PMID: 28098152 Free PMC article.

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