Klinman JP - Search Results

1

Detecting and Characterizing the Kinetic Activation of Thermal Networks in Proteins: Thermal Transfer from a Distal, Solvent-Exposed Loop to the Active Site in Soybean Lipoxygenase.

Zaragoza JPT, Nguy A, Minnetian N, Deng Z, Iavarone AT, Offenbacher AR, Klinman JP. Zaragoza JPT, et al. Among authors: klinman jp. J Phys Chem B. 2019 Oct 17;123(41):8662-8674. doi: 10.1021/acs.jpcb.9b07228. Epub 2019 Oct 3. J Phys Chem B. 2019. PMID: 31580070 Free PMC article.

2

Temperature-dependent isotope effects in soybean lipoxygenase-1: correlating hydrogen tunneling with protein dynamics.

Knapp MJ, Rickert K, Klinman JP. Knapp MJ, et al. Among authors: klinman jp. J Am Chem Soc. 2002 Apr 17;124(15):3865-74. doi: 10.1021/ja012205t. J Am Chem Soc. 2002. PMID: 11942823

3

Kinetic studies of oxygen reactivity in soybean lipoxygenase-1.

Knapp MJ, Klinman JP. Knapp MJ, et al. Among authors: klinman jp. Biochemistry. 2003 Oct 7;42(39):11466-75. doi: 10.1021/bi0300884. Biochemistry. 2003. PMID: 14516198

4

Interaction of PqqE and PqqD in the pyrroloquinoline quinone (PQQ) biosynthetic pathway links PqqD to the radical SAM superfamily.

Wecksler SR, Stoll S, Iavarone AT, Imsand EM, Tran H, Britt RD, Klinman JP. Wecksler SR, et al. Among authors: klinman jp. Chem Commun (Camb). 2010 Oct 7;46(37):7031-3. doi: 10.1039/c0cc00968g. Epub 2010 Aug 25. Chem Commun (Camb). 2010. PMID: 20737074

5

Investigating inner-sphere reorganization via secondary kinetic isotope effects in the C-H cleavage reaction catalyzed by soybean lipoxygenase: tunneling in the substrate backbone as well as the transferred hydrogen.

Meyer MP, Klinman JP. Meyer MP, et al. Among authors: klinman jp. J Am Chem Soc. 2011 Jan 26;133(3):430-9. doi: 10.1021/ja1050742. Epub 2010 Dec 30. J Am Chem Soc. 2011. PMID: 21192631 Free PMC article.

6

Inactivation of Met471Cys tyramine β-monooxygenase results from site-specific cysteic acid formation.

Osborne RL, Zhu H, Iavarone AT, Hess CR, Klinman JP. Osborne RL, et al. Among authors: klinman jp. Biochemistry. 2012 Sep 25;51(38):7488-95. doi: 10.1021/bi300456f. Epub 2012 Sep 12. Biochemistry. 2012. PMID: 22891760 Free PMC article.

7

Interdomain long-range electron transfer becomes rate-limiting in the Y216A variant of tyramine β-monooxygenase.

Osborne RL, Zhu H, Iavarone AT, Blackburn NJ, Klinman JP. Osborne RL, et al. Among authors: klinman jp. Biochemistry. 2013 Feb 19;52(7):1179-91. doi: 10.1021/bi3013609. Epub 2013 Feb 6. Biochemistry. 2013. PMID: 23320946 Free PMC article.

8

Multistep, eight-electron oxidation catalyzed by the cofactorless oxidase, PqqC: identification of chemical intermediates and their dependence on molecular oxygen.

Bonnot F, Iavarone AT, Klinman JP. Bonnot F, et al. Among authors: klinman jp. Biochemistry. 2013 Jul 9;52(27):4667-75. doi: 10.1021/bi4003315. Epub 2013 Jun 25. Biochemistry. 2013. PMID: 23718207 Free PMC article.

9

Hydrogen tunneling in a prokaryotic lipoxygenase.

Carr CA, Klinman JP. Carr CA, et al. Among authors: klinman jp. Biochemistry. 2014 Apr 15;53(14):2212-4. doi: 10.1021/bi500070q. Epub 2014 Apr 3. Biochemistry. 2014. PMID: 24641705 Free PMC article.

10

Extremely elevated room-temperature kinetic isotope effects quantify the critical role of barrier width in enzymatic C-H activation.

Hu S, Sharma SC, Scouras AD, Soudackov AV, Carr CA, Hammes-Schiffer S, Alber T, Klinman JP. Hu S, et al. Among authors: klinman jp. J Am Chem Soc. 2014 Jun 11;136(23):8157-60. doi: 10.1021/ja502726s. Epub 2014 Jun 2. J Am Chem Soc. 2014. PMID: 24884374 Free PMC article.

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