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519 results

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Bitopertin, a selective oral GLYT1 inhibitor, improves anemia in a mouse model of β-thalassemia.
Matte A, Federti E, Winter M, Koerner A, Harmeier A, Mazer N, Tomka T, Di Paolo ML, De Falco L, Andolfo I, Beneduce E, Iolascon A, Macias-Garcia A, Chen JJ, Janin A, Lebouef C, Turrini F, Brugnara C, De Franceschi L. Matte A, et al. Among authors: janin a. JCI Insight. 2019 Nov 14;4(22):e130111. doi: 10.1172/jci.insight.130111. JCI Insight. 2019. PMID: 31593554 Free PMC article.
The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model.
Matte A, Federti E, Kung C, Kosinski PA, Narayanaswamy R, Russo R, Federico G, Carlomagno F, Desbats MA, Salviati L, Leboeuf C, Valenti MT, Turrini F, Janin A, Yu S, Beneduce E, Ronseaux S, Iatcenko I, Dang L, Ganz T, Jung CL, Iolascon A, Brugnara C, De Franceschi L. Matte A, et al. Among authors: janin a. J Clin Invest. 2021 May 17;131(10):e144206. doi: 10.1172/JCI144206. J Clin Invest. 2021. PMID: 33822774 Free PMC article.
The Interplay Between Peroxiredoxin-2 and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in β-Thalassemic Erythropoiesis.
Matte A, De Falco L, Iolascon A, Mohandas N, An X, Siciliano A, Leboeuf C, Janin A, Bruno M, Choi SY, Kim DW, De Franceschi L. Matte A, et al. Among authors: janin a. Antioxid Redox Signal. 2015 Dec 1;23(16):1284-97. doi: 10.1089/ars.2014.6237. Epub 2015 Jul 14. Antioxid Redox Signal. 2015. PMID: 26058667 Free PMC article.
Peroxiredoxin-2: A Novel Regulator of Iron Homeostasis in Ineffective Erythropoiesis.
Matte A, De Falco L, Federti E, Cozzi A, Iolascon A, Levi S, Mohandas N, Zamo A, Bruno M, Lebouef C, Janin A, Siciliano A, Ganz T, Federico G, Carlomagno F, Mueller S, Silva I, Carbone C, Melisi D, Kim DW, Choi SY, De Franceschi L. Matte A, et al. Among authors: janin a. Antioxid Redox Signal. 2018 Jan 1;28(1):1-14. doi: 10.1089/ars.2017.7051. Epub 2017 Sep 6. Antioxid Redox Signal. 2018. PMID: 28793778
Peroxiredoxin-2 plays a pivotal role as multimodal cytoprotector in the early phase of pulmonary hypertension.
Federti E, Matté A, Ghigo A, Andolfo I, James C, Siciliano A, Leboeuf C, Janin A, Manna F, Choi SY, Iolascon A, Beneduce E, Melisi D, Kim DW, Levi S, De Franceschi L. Federti E, et al. Among authors: janin a. Free Radic Biol Med. 2017 Nov;112:376-386. doi: 10.1016/j.freeradbiomed.2017.08.004. Epub 2017 Aug 9. Free Radic Biol Med. 2017. PMID: 28801243
Protective effects of S-nitrosoalbumin on lung injury induced by hypoxia-reoxygenation in mouse model of sickle cell disease.
de Franceschi L, Malpeli G, Scarpa A, Janin A, Muchitsch EM, Roncada P, Leboeuf C, Corrocher R, Beuzard Y, Brugnara C. de Franceschi L, et al. Among authors: janin a. Am J Physiol Lung Cell Mol Physiol. 2006 Sep;291(3):L457-65. doi: 10.1152/ajplung.00462.2005. Epub 2006 Apr 7. Am J Physiol Lung Cell Mol Physiol. 2006. PMID: 16603592 Free article.
Abnormal modulation of cell protective systems in response to ischemic/reperfusion injury is important in the development of mouse sickle cell hepatopathy.
Siciliano A, Malpeli G, Platt OS, Lebouef C, Janin A, Scarpa A, Olivieri O, Amato E, Corrocher R, Beuzard Y, De Franceschi L. Siciliano A, et al. Among authors: janin a. Haematologica. 2011 Jan;96(1):24-32. doi: 10.3324/haematol.2010.028506. Epub 2010 Sep 17. Haematologica. 2011. PMID: 20851863 Free PMC article.
519 results