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Bitopertin, a selective oral GLYT1 inhibitor, improves anemia in a mouse model of β-thalassemia.
Matte A, Federti E, Winter M, Koerner A, Harmeier A, Mazer N, Tomka T, Di Paolo ML, De Falco L, Andolfo I, Beneduce E, Iolascon A, Macias-Garcia A, Chen JJ, Janin A, Lebouef C, Turrini F, Brugnara C, De Franceschi L. Matte A, et al. Among authors: turrini f. JCI Insight. 2019 Nov 14;4(22):e130111. doi: 10.1172/jci.insight.130111. JCI Insight. 2019. PMID: 31593554 Free PMC article.
Peroxiredoxin-2 expression is increased in beta-thalassemic mouse red cells but is displaced from the membrane as a marker of oxidative stress.
Matte A, Low PS, Turrini F, Bertoldi M, Campanella ME, Spano D, Pantaleo A, Siciliano A, De Franceschi L. Matte A, et al. Among authors: turrini f. Free Radic Biol Med. 2010 Aug 1;49(3):457-66. doi: 10.1016/j.freeradbiomed.2010.05.003. Epub 2010 May 19. Free Radic Biol Med. 2010. PMID: 20488244 Free PMC article.
Oxidative stress modulates heme synthesis and induces peroxiredoxin-2 as a novel cytoprotective response in β-thalassemic erythropoiesis.
De Franceschi L, Bertoldi M, De Falco L, Santos Franco S, Ronzoni L, Turrini F, Colancecco A, Camaschella C, Cappellini MD, Iolascon A. De Franceschi L, et al. Among authors: turrini f. Haematologica. 2011 Nov;96(11):1595-604. doi: 10.3324/haematol.2011.043612. Epub 2011 Jul 12. Haematologica. 2011. PMID: 21750082 Free PMC article. Clinical Trial.
228 results