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Page 1
Effects of antineoplastic drugs on the post-strand-passage DNA cleavage/religation equilibrium of topoisomerase II.
Robinson MJ, Osheroff N. Robinson MJ, et al. Among authors: osheroff n. Biochemistry. 1991 Feb 19;30(7):1807-13. doi: 10.1021/bi00221a012. Biochemistry. 1991. PMID: 1847075
Since previous studies demonstrated that antineoplastic drugs stabilize the pre-strand-passage cleavage complex of topoisomerase II by impairing the enzyme's ability to religate cleaved DNA [Osheroff, N. (1989) Biochemistry 28, 6157-6160; Robinson, M.J., & Os …
Since previous studies demonstrated that antineoplastic drugs stabilize the pre-strand-passage cleavage complex of topoisomerase II by impai …
Stabilization of the topoisomerase II-DNA cleavage complex by antineoplastic drugs: inhibition of enzyme-mediated DNA religation by 4'-(9-acridinylamino)methanesulfon-m-anisidide.
Robinson MJ, Osheroff N. Robinson MJ, et al. Among authors: osheroff n. Biochemistry. 1990 Mar 13;29(10):2511-5. doi: 10.1021/bi00462a012. Biochemistry. 1990. PMID: 2159323
This result is similar to that previously reported for the effects of etoposide on the activity of the Drosophila enzyme [Osheroff, N. (1989) Biochemistry 28, 6157-6160]. Thus, it appears that structurally disparate classes of topoisomerase II targeted antineoplasti …
This result is similar to that previously reported for the effects of etoposide on the activity of the Drosophila enzyme [Osheroff, …
Effect of antineoplastic agents on the DNA cleavage/religation reaction of eukaryotic topoisomerase II: inhibition of DNA religation by etoposide.
Osheroff N. Osheroff N. Biochemistry. 1989 Jul 25;28(15):6157-60. doi: 10.1021/bi00441a005. Biochemistry. 1989. PMID: 2551366
By employing a topoisomerase II mediated DNA religation assay [Osheroff, N. & Zechiedrich, E.L. (1987) Biochemistry 26, 4303-4309], etoposide was found to stabilize the enzyme-DNA cleavage complex (at least in part) by inhibiting the enzyme's ability to religate …
By employing a topoisomerase II mediated DNA religation assay [Osheroff, N. & Zechiedrich, E.L. (1987) Biochemistry 26, 43 …
Double-stranded DNA cleavage/religation reaction of eukaryotic topoisomerase II: evidence for a nicked DNA intermediate.
Zechiedrich EL, Christiansen K, Andersen AH, Westergaard O, Osheroff N. Zechiedrich EL, et al. Among authors: osheroff n. Biochemistry. 1989 Jul 25;28(15):6229-36. doi: 10.1021/bi00441a014. Biochemistry. 1989. PMID: 2551367
Finally, by use of a novel religation assay [Osheroff, N., & Zechiedrich, E. L. (1987) Biochemistry 26, 4303-4309], it was shown that nicked DNA is an obligatory kinetic intermediate in the topoisomerase II mediated reunion of double-stranded breaks. ...
Finally, by use of a novel religation assay [Osheroff, N., & Zechiedrich, E. L. (1987) Biochemistry 26, 4303-4309], it was …
Protein kinase C modulates the catalytic activity of topoisomerase II by enhancing the rate of ATP hydrolysis: evidence for a common mechanism of regulation by phosphorylation.
Corbett AH, Fernald AW, Osheroff N. Corbett AH, et al. Among authors: osheroff n. Biochemistry. 1993 Mar 2;32(8):2090-7. doi: 10.1021/bi00059a029. Biochemistry. 1993. PMID: 8383533
A previous study [Corbett, A. H., DeVore, R. F., & Osheroff, N. (1992) J. Biol. Chem. 267, 20513-20518] demonstrated that casein kinase II regulates the activity of topoisomerase II by specifically enhancing the ability of the enzyme to hydrolyze its ATP cofacto …
A previous study [Corbett, A. H., DeVore, R. F., & Osheroff, N. (1992) J. Biol. Chem. 267, 20513-20518] demonstrated that …
Quinolones share a common interaction domain on topoisomerase II with other DNA cleavage-enhancing antineoplastic drugs.
Elsea SH, Westergaard M, Burden DA, Lomenick JP, Osheroff N. Elsea SH, et al. Among authors: osheroff n. Biochemistry. 1997 Mar 11;36(10):2919-24. doi: 10.1021/bi962488f. Biochemistry. 1997. PMID: 9062121
Despite the fact that these agents differ significantly in structure, a previous study [Corbett, A. H., Hong, D., & Osheroff, N. (1993) J. Biol. Chem. 268, 14394-14398] indicated that the site of action for etoposide on topoisomerase II overlaps those of other D …
Despite the fact that these agents differ significantly in structure, a previous study [Corbett, A. H., Hong, D., & Osheroff, …
245 results