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Relative contributions of the major human CYP450 to the metabolism of icotinib and its implication in prediction of drug-drug interaction between icotinib and CYP3A4 inhibitors/inducers using physiologically based pharmacokinetic modeling.
Chen J, Liu D, Zheng X, Zhao Q, Jiang J, Hu P. Chen J, et al. Among authors: zheng x. Expert Opin Drug Metab Toxicol. 2015 Jun;11(6):857-68. doi: 10.1517/17425255.2015.1034688. Epub 2015 Apr 8. Expert Opin Drug Metab Toxicol. 2015. PMID: 25850339
Development of an UPLC-MS/MS method for quantification of Avitinib (AC0010) and its five metabolites in human cerebrospinal fluid: Application to a study of the blood-brain barrier penetration rate of non-small cell lung cancer patients.
Wang W, Zheng X, Wang H, Wang L, Jiang J, Hu P. Wang W, et al. Among authors: zheng x. J Pharm Biomed Anal. 2017 May 30;139:205-214. doi: 10.1016/j.jpba.2017.02.057. Epub 2017 Mar 4. J Pharm Biomed Anal. 2017. PMID: 28285073
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