Spencer J - Search Results

1

A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C.

Bauer MR, Jones RN, Tareque RK, Springett B, Dingler FA, Verduci L, Patel KJ, Fersht AR, Joerger AC, Spencer J. Bauer MR, et al. Among authors: spencer j. Future Med Chem. 2019 Oct;11(19):2491-2504. doi: 10.4155/fmc-2019-0181. Future Med Chem. 2019. PMID: 31633398 Free PMC article.

2

Small molecule induced reactivation of mutant p53 in cancer cells.

Liu X, Wilcken R, Joerger AC, Chuckowree IS, Amin J, Spencer J, Fersht AR. Liu X, et al. Among authors: spencer j. Nucleic Acids Res. 2013 Jul;41(12):6034-44. doi: 10.1093/nar/gkt305. Epub 2013 Apr 29. Nucleic Acids Res. 2013. PMID: 23630318 Free PMC article.

3

Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53.

Joerger AC, Bauer MR, Wilcken R, Baud MGJ, Harbrecht H, Exner TE, Boeckler FM, Spencer J, Fersht AR. Joerger AC, et al. Among authors: spencer j. Structure. 2015 Dec 1;23(12):2246-2255. doi: 10.1016/j.str.2015.10.016. Structure. 2015. PMID: 26636255 Free PMC article.

4

A synthetic, catalytic and theoretical investigation of an unsymmetrical SCN pincer palladacycle.

Roffe GW, Boonseng S, Baltus CB, Coles SJ, Day IJ, Jones RN, Press NJ, Ruiz M, Tizzard GJ, Cox H, Spencer J. Roffe GW, et al. Among authors: spencer j. R Soc Open Sci. 2016 Apr 6;3(4):150656. doi: 10.1098/rsos.150656. eCollection 2016 Apr. R Soc Open Sci. 2016. PMID: 27152207 Free PMC article.

5

Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs.

Bauer MR, Jones RN, Baud MG, Wilcken R, Boeckler FM, Fersht AR, Joerger AC, Spencer J. Bauer MR, et al. Among authors: spencer j. ACS Chem Biol. 2016 Aug 19;11(8):2265-74. doi: 10.1021/acschembio.6b00315. Epub 2016 Jun 21. ACS Chem Biol. 2016. PMID: 27267810 Free PMC article.

6

Elaboration of tetra-orthogonally-substituted aromatic scaffolds towards novel EGFR-kinase inhibitors.

Close AJ, Jones RN, Ocasio CA, Kemmitt P, Roe SM, Spencer J. Close AJ, et al. Among authors: spencer j. Org Biomol Chem. 2016 Sep 21;14(35):8246-52. doi: 10.1039/c6ob01394e. Epub 2016 Jul 25. Org Biomol Chem. 2016. PMID: 27453149

7

Dual abrogation of MNK and mTOR: a novel therapeutic approach for the treatment of aggressive cancers.

Lineham E, Spencer J, Morley SJ. Lineham E, et al. Among authors: spencer j. Future Med Chem. 2017 Sep;9(13):1539-1555. doi: 10.4155/fmc-2017-0062. Epub 2017 Aug 25. Future Med Chem. 2017. PMID: 28841037 Free article. Review.

8

Development of novel oxazolo[5,4-d]pyrimidines as competitive CB₂ neutral antagonists based on scaffold hopping.

Tuo W, Bollier M, Leleu-Chavain N, Lemaire L, Barczyk A, Dezitter X, Klupsch F, Szczepanski F, Spencer J, Chavatte P, Millet R. Tuo W, et al. Among authors: spencer j. Eur J Med Chem. 2018 Feb 25;146:68-78. doi: 10.1016/j.ejmech.2018.01.034. Epub 2018 Jan 16. Eur J Med Chem. 2018. PMID: 29360044

9

Synthesis and biological evaluation of ferrocene-based cannabinoid receptor 2 ligands.

Sansook S, Tuo W, Bollier M, Barczyk A, Dezitter X, Klupsch F, Leleu-Chavain N, Farce A, Tizzard GJ, Coles SJ, Spencer J, Millet R. Sansook S, et al. Among authors: spencer j. Future Med Chem. 2018 Mar 1;10(6):631-638. doi: 10.4155/fmc-2017-0200. Epub 2018 Feb 8. Future Med Chem. 2018. PMID: 29419319 Free article.

10

Special focus: metals in medicine.

Spencer J, Walden B. Spencer J, et al. Future Med Chem. 2018 Mar 1;10(6):607-609. doi: 10.4155/fmc-2018-9999. Future Med Chem. 2018. PMID: 29508658 Free article. No abstract available.

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