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Delayed low-dose oral administration of 4'-fluorouridine inhibits pathogenic arenaviruses in animal models of lethal disease.
Welch SR, Spengler JR, Westover JB, Bailey KW, Davies KA, Aida-Ficken V, Bluemling GR, Boardman KM, Wasson SR, Mao S, Kuiper DL, Hager MW, Saindane MT, Andrews MK, Krueger RE, Sticher ZM, Jung KH, Chatterjee P, Shrivastava-Ranjan P, Lo MK, Coleman-McCray JD, Sorvillo TE, Genzer SC, Scholte FEM, Kelly JA, Jenks MH, McMullan LK, Albariño CG, Montgomery JM, Painter GR, Natchus MG, Kolykhalov AA, Gowen BB, Spiropoulou CF, Flint M. Welch SR, et al. Among authors: wasson sr. Sci Transl Med. 2024 Nov 20;16(774):eado7034. doi: 10.1126/scitranslmed.ado7034. Epub 2024 Nov 20. Sci Transl Med. 2024. PMID: 39565871
Restoration of virulence in the attenuated Candid#1 vaccine virus requires reversion at both positions 168 and 427 in the envelope glycoprotein GPC.
Nunberg JH, Westover JB, York J, Jung KH, Bailey KW, Boardman KM, Li M, Furnell RS, Wasson SR, Murray JS, Kaundal R, Thomas AJ, Gowen BB. Nunberg JH, et al. Among authors: wasson sr. J Virol. 2024 Apr 16;98(4):e0011224. doi: 10.1128/jvi.00112-24. Epub 2024 Mar 20. J Virol. 2024. PMID: 38506509 Free PMC article.
47 results