van Lier JJ - Search Results

1

Oral ferroportin inhibitor VIT-2763: First-in-human, phase 1 study in healthy volunteers.

Richard F, van Lier JJ, Roubert B, Haboubi T, Göhring UM, Dürrenberger F. Richard F, et al. Among authors: van lier jj. Am J Hematol. 2020 Jan;95(1):68-77. doi: 10.1002/ajh.25670. Epub 2019 Nov 19. Am J Hematol. 2020. PMID: 31674058 Free PMC article. Clinical Trial.

2

First-in-Human Study of the Safety, Tolerability, Pharmacokinetics and - Preliminary Dynamics of Neuroprotectant 2-Iminobiotin in Healthy Subjects.

van Hoogdalem EJ, Peeters-Scholte CMPCD, Leufkens PWTJ, Hartstra J, van Lier JJ, de Leede LGJ. van Hoogdalem EJ, et al. Among authors: van lier jj. Curr Clin Pharmacol. 2020;15(2):152-163. doi: 10.2174/1574884714666191017111109. Curr Clin Pharmacol. 2020. PMID: 31625480 Free PMC article. Clinical Trial.

3

Open-label, single-center, phase I trial to investigate the mass balance and absolute bioavailability of the highly selective oral MET inhibitor tepotinib in healthy volunteers.

Johne A, Scheible H, Becker A, van Lier JJ, Wolna P, Meyring M. Johne A, et al. Among authors: van lier jj. Invest New Drugs. 2020 Oct;38(5):1507-1519. doi: 10.1007/s10637-020-00926-1. Epub 2020 Mar 27. Invest New Drugs. 2020. PMID: 32221754 Free PMC article. Clinical Trial.

4

First-in-human study evaluating safety, pharmacokinetics, and pharmacodynamics of lorundrostat, a novel and highly selective aldosterone synthase inhibitor.

Shimizu H, Tortorici MA, Ohta Y, Ogawa K, Rahman SMA, Fujii A, Hiraga Y, Kawai M, Sugimoto-Kawabata K, van Iersel MT, van Lier JJ, Djedjos S, Slingsby BT, Rodman DM. Shimizu H, et al. Among authors: van lier jj. Clin Transl Sci. 2024 Aug;17(8):e70000. doi: 10.1111/cts.70000. Clin Transl Sci. 2024. PMID: 39152532 Free PMC article. Clinical Trial.

5

Evobrutinib, a covalent Bruton's tyrosine kinase inhibitor: Mass balance, elimination route, and metabolism in healthy participants.

Scheible H, Dyroff M, Seithel-Keuth A, Harrison-Moench E, Mammasse N, Port A, Bachmann A, Dong J, van Lier JJ, Tracewell W, Mitchell D. Scheible H, et al. Among authors: van lier jj. Clin Transl Sci. 2021 Nov;14(6):2420-2430. doi: 10.1111/cts.13108. Epub 2021 Aug 10. Clin Transl Sci. 2021. PMID: 34374206 Free PMC article.

6

An evaluation of human ADME and mass balance studies using regular or low doses of radiocarbon.

Roffel AF, van Marle SP, van Lier JJ, Hartstra J, van Hoogdalem EJ. Roffel AF, et al. Among authors: van lier jj. J Labelled Comp Radiopharm. 2016 Dec;59(14):619-626. doi: 10.1002/jlcr.3473. J Labelled Comp Radiopharm. 2016. PMID: 28000265 Review.

7

Absorption, Distribution, Metabolism, and Excretion of [¹⁴C]iptacopan in Healthy Male Volunteers and in In Vivo and In Vitro Studies.

James AD, Kulmatycki K, Poller B, Romeo AA, Van Lier JJ, Klein K, Pearson D. James AD, et al. Among authors: van lier jj. Drug Metab Dispos. 2023 Jul;51(7):873-883. doi: 10.1124/dmd.123.001290. Epub 2023 Jun 12. Drug Metab Dispos. 2023. PMID: 37308298

8

Pharmacokinetics of [14C]-labelled Losigamone and enantiomers after oral administration to healthy subjects.

Peeters PA, Van Lier JJ, Van De Merbel N, Oosterhuis B, Wieling J, Jonkman JH, Klessing K, Biber A. Peeters PA, et al. Among authors: van de merbel n, van lier jj. Eur J Drug Metab Pharmacokinet. 1998 Jan-Mar;23(1):45-53. doi: 10.1007/BF03189826. Eur J Drug Metab Pharmacokinet. 1998. PMID: 9625272 Clinical Trial.

9

Absorption, distribution, metabolism, and excretion of cenerimod, a selective S1P₁ receptor modulator in healthy subjects.

Boof ML, van Lier JJ, English S, Fischer H, Ufer M, Dingemanse J. Boof ML, et al. Among authors: van lier jj. Xenobiotica. 2020 Aug;50(8):947-956. doi: 10.1080/00498254.2020.1736688. Epub 2020 Mar 9. Xenobiotica. 2020. PMID: 32105166

10

Absorption, distribution, metabolism and excretion of the P2Y12 receptor antagonist selatogrel after subcutaneous administration in healthy subjects.

Ufer M, Huynh C, van Lier JJ, Caroff E, Fischer H, Dingemanse J. Ufer M, et al. Among authors: van lier jj. Xenobiotica. 2020 Apr;50(4):427-434. doi: 10.1080/00498254.2019.1646440. Epub 2019 Aug 7. Xenobiotica. 2020. PMID: 31322041

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