Almqvist H - Search Results

1

Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.

Page BDG, Valerie NCK, Wright RHG, Wallner O, Isaksson R, Carter M, Rudd SG, Loseva O, Jemth AS, Almlöf I, Font-Mateu J, Llona-Minguez S, Baranczewski P, Jeppsson F, Homan E, Almqvist H, Axelsson H, Regmi S, Gustavsson AL, Lundbäck T, Scobie M, Strömberg K, Stenmark P, Beato M, Helleday T. Page BDG, et al. Among authors: almqvist h. Nat Commun. 2019 Nov 1;10(1):5050. doi: 10.1038/s41467-019-12806-1. Nat Commun. 2019. PMID: 31676755 Free PMC article.

2

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.

Page BDG, Valerie NCK, Wright RHG, Wallner O, Isaksson R, Carter M, Rudd SG, Loseva O, Jemth AS, Almlöf I, Font-Mateu J, Llona-Minguez S, Baranczewski P, Jeppsson F, Homan E, Almqvist H, Axelsson H, Regmi S, Gustavsson AL, Lundbäck T, Scobie M, Strömberg K, Stenmark P, Beato M, Helleday T. Page BDG, et al. Among authors: almqvist h. Nat Commun. 2018 Jan 17;9(1):250. doi: 10.1038/s41467-017-02293-7. Nat Commun. 2018. PMID: 29343827 Free PMC article.

3

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.

Almqvist H, Axelsson H, Jafari R, Dan C, Mateus A, Haraldsson M, Larsson A, Martinez Molina D, Artursson P, Lundbäck T, Nordlund P. Almqvist H, et al. Nat Commun. 2016 Mar 24;7:11040. doi: 10.1038/ncomms11040. Nat Commun. 2016. PMID: 27010513 Free PMC article.

4

The cellular thermal shift assay for evaluating drug target interactions in cells.

Jafari R, Almqvist H, Axelsson H, Ignatushchenko M, Lundbäck T, Nordlund P, Martinez Molina D. Jafari R, et al. Among authors: almqvist h. Nat Protoc. 2014 Sep;9(9):2100-22. doi: 10.1038/nprot.2014.138. Epub 2014 Aug 7. Nat Protoc. 2014. PMID: 25101824

5

Quantitative Interpretation of Intracellular Drug Binding and Kinetics Using the Cellular Thermal Shift Assay.

Seashore-Ludlow B, Axelsson H, Almqvist H, Dahlgren B, Jonsson M, Lundbäck T. Seashore-Ludlow B, et al. Among authors: almqvist h. Biochemistry. 2018 Dec 4;57(48):6715-6725. doi: 10.1021/acs.biochem.8b01057. Epub 2018 Nov 19. Biochemistry. 2018. PMID: 30418016

6

Using High Content Imaging to Quantify Target Engagement in Adherent Cells.

Axelsson H, Almqvist H, Seashore-Ludlow B. Axelsson H, et al. Among authors: almqvist h. J Vis Exp. 2018 Nov 29;(141). doi: 10.3791/58670. J Vis Exp. 2018. PMID: 30582591

7

In Situ Target Engagement Studies in Adherent Cells.

Axelsson H, Almqvist H, Otrocka M, Vallin M, Lundqvist S, Hansson P, Karlsson U, Lundbäck T, Seashore-Ludlow B. Axelsson H, et al. Among authors: almqvist h. ACS Chem Biol. 2018 Apr 20;13(4):942-950. doi: 10.1021/acschembio.7b01079. Epub 2018 Feb 21. ACS Chem Biol. 2018. PMID: 29433316

8

A FabG inhibitor targeting an allosteric binding site inhibits several orthologs from Gram-negative ESKAPE pathogens.

Vella P, Rudraraju RS, Lundbäck T, Axelsson H, Almqvist H, Vallin M, Schneider G, Schnell R. Vella P, et al. Among authors: almqvist h. Bioorg Med Chem. 2021 Jan 15;30:115898. doi: 10.1016/j.bmc.2020.115898. Epub 2020 Dec 5. Bioorg Med Chem. 2021. PMID: 33388594 Free article.

9

Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.

Brunner K, Maric S, Reshma RS, Almqvist H, Seashore-Ludlow B, Gustavsson AL, Poyraz Ö, Yogeeswari P, Lundbäck T, Vallin M, Sriram D, Schnell R, Schneider G. Brunner K, et al. Among authors: almqvist h. J Med Chem. 2016 Jul 28;59(14):6848-59. doi: 10.1021/acs.jmedchem.6b00674. Epub 2016 Jul 13. J Med Chem. 2016. PMID: 27379713 Free article.

10

Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery.

Mateus A, Gordon LJ, Wayne GJ, Almqvist H, Axelsson H, Seashore-Ludlow B, Treyer A, Matsson P, Lundbäck T, West A, Hann MM, Artursson P. Mateus A, et al. Among authors: almqvist h. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6231-E6239. doi: 10.1073/pnas.1701848114. Epub 2017 Jul 12. Proc Natl Acad Sci U S A. 2017. PMID: 28701380 Free PMC article.

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