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KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2.
Spiombi E, Angrisani A, Fonte S, De Feudis G, Fabretti F, Cucchi D, Izzo M, Infante P, Miele E, Po A, Di Magno L, Magliozzi R, Guardavaccaro D, Maroder M, Canettieri G, Giannini G, Ferretti E, Gulino A, Di Marcotullio L, Moretti M, De Smaele E. Spiombi E, et al. Among authors: cucchi d. Oncogenesis. 2019 Nov 4;8(11):64. doi: 10.1038/s41389-019-0175-6. Oncogenesis. 2019. PMID: 31685809 Free PMC article.
Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma.
De Smaele E, Di Marcotullio L, Moretti M, Pelloni M, Occhione MA, Infante P, Cucchi D, Greco A, Pietrosanti L, Todorovic J, Coni S, Canettieri G, Ferretti E, Bei R, Maroder M, Screpanti I, Gulino A. De Smaele E, et al. Among authors: cucchi d. Neoplasia. 2011 Apr;13(4):374-85. doi: 10.1593/neo.101630. Neoplasia. 2011. PMID: 21472142 Free PMC article.
Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.
Infante P, Mori M, Alfonsi R, Ghirga F, Aiello F, Toscano S, Ingallina C, Siler M, Cucchi D, Po A, Miele E, D'Amico D, Canettieri G, De Smaele E, Ferretti E, Screpanti I, Uccello Barretta G, Botta M, Botta B, Gulino A, Di Marcotullio L. Infante P, et al. Among authors: d amico d, cucchi d. EMBO J. 2015 Jan 13;34(2):200-17. doi: 10.15252/embj.201489213. Epub 2014 Dec 4. EMBO J. 2015. PMID: 25476449 Free PMC article.
β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells.
Miele E, Po A, Begalli F, Antonucci L, Mastronuzzi A, Marras CE, Carai A, Cucchi D, Abballe L, Besharat ZM, Catanzaro G, Infante P, Di Marcotullio L, Canettieri G, De Smaele E, Screpanti I, Locatelli F, Ferretti E. Miele E, et al. Among authors: cucchi d. BMC Cancer. 2017 Jul 17;17(1):488. doi: 10.1186/s12885-017-3477-0. BMC Cancer. 2017. PMID: 28716052 Free PMC article.
Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma.
Po A, Silvano M, Miele E, Capalbo C, Eramo A, Salvati V, Todaro M, Besharat ZM, Catanzaro G, Cucchi D, Coni S, Di Marcotullio L, Canettieri G, Vacca A, Stassi G, De Smaele E, Tartaglia M, Screpanti I, De Maria R, Ferretti E. Po A, et al. Among authors: cucchi d. Oncogene. 2017 Aug 10;36(32):4641-4652. doi: 10.1038/onc.2017.91. Epub 2017 Apr 3. Oncogene. 2017. PMID: 28368412 Free PMC article.
In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors.
Benvenuto M, Masuelli L, De Smaele E, Fantini M, Mattera R, Cucchi D, Bonanno E, Di Stefano E, Frajese GV, Orlandi A, Screpanti I, Gulino A, Modesti A, Bei R. Benvenuto M, et al. Among authors: cucchi d. Oncotarget. 2016 Feb 23;7(8):9250-70. doi: 10.18632/oncotarget.7062. Oncotarget. 2016. PMID: 26843616 Free PMC article.
Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals.
Mauro C, Smith J, Cucchi D, Coe D, Fu H, Bonacina F, Baragetti A, Cermenati G, Caruso D, Mitro N, Catapano AL, Ammirati E, Longhi MP, Okkenhaug K, Norata GD, Marelli-Berg FM. Mauro C, et al. Among authors: cucchi d. Cell Metab. 2017 Mar 7;25(3):593-609. doi: 10.1016/j.cmet.2017.01.008. Epub 2017 Feb 9. Cell Metab. 2017. PMID: 28190771 Free PMC article.
128 results