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Page 1
Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors.
Engelhardt H, Böse D, Petronczki M, Scharn D, Bader G, Baum A, Bergner A, Chong E, Döbel S, Egger G, Engelhardt C, Ettmayer P, Fuchs JE, Gerstberger T, Gonnella N, Grimm A, Grondal E, Haddad N, Hopfgartner B, Kousek R, Krawiec M, Kriz M, Lamarre L, Leung J, Mayer M, Patel ND, Simov BP, Reeves JT, Schnitzer R, Schrenk A, Sharps B, Solca F, Stadtmüller H, Tan Z, Wunberg T, Zoephel A, McConnell DB. Engelhardt H, et al. Among authors: patel nd. J Med Chem. 2019 Nov 27;62(22):10272-10293. doi: 10.1021/acs.jmedchem.9b01169. Epub 2019 Nov 13. J Med Chem. 2019. PMID: 31689114 Free article.
A general and special catalyst for Suzuki-Miyaura coupling processes.
Tang W, Capacci AG, Wei X, Li W, White A, Patel ND, Savoie J, Gao JJ, Rodriguez S, Qu B, Haddad N, Lu BZ, Krishnamurthy D, Yee NK, Senanayake CH. Tang W, et al. Among authors: patel nd. Angew Chem Int Ed Engl. 2010 Aug 9;49(34):5879-83. doi: 10.1002/anie.201002404. Angew Chem Int Ed Engl. 2010. PMID: 20632427 No abstract available.
Concise and Practical Asymmetric Synthesis of a Challenging Atropisomeric HIV Integrase Inhibitor.
Fandrick KR, Li W, Zhang Y, Tang W, Gao J, Rodriguez S, Patel ND, Reeves DC, Wu JP, Sanyal S, Gonnella N, Qu B, Haddad N, Lorenz JC, Sidhu K, Wang J, Ma S, Grinberg N, Lee H, Tsantrizos Y, Poupart MA, Busacca CA, Yee NK, Lu BZ, Senanayake CH. Fandrick KR, et al. Among authors: patel nd. Angew Chem Int Ed Engl. 2015 Jun 8;54(24):7144-8. doi: 10.1002/anie.201501575. Epub 2015 May 4. Angew Chem Int Ed Engl. 2015. PMID: 25939331
Sulfone-Mediated SNAr Reaction as a Powerful Tool for the Synthesis of 4-Quinolinyl Ethers and More-Application to the Synthesis of HCV NS3/4a Protease Inhibitor BI 201420.
Patel ND, Wei X, Byrne D, Narayanan BA, Pennino S, Sarvestani M, Saha A, Haddad N, Kapadia S, Lorenz JC, DeCroos P, Ye A, Lee H, Grinberg N, Hossain A, Busacca CA, Yee NK, Senanayake CH. Patel ND, et al. J Org Chem. 2020 Jul 2;85(13):8339-8351. doi: 10.1021/acs.joc.0c00554. Epub 2020 Jun 19. J Org Chem. 2020. PMID: 32462862
Sequential C-H Arylation and Enantioselective Hydrogenation Enables Ideal Asymmetric Entry to the Indenopiperidine Core of an 11β-HSD-1 Inhibitor.
Wei X, Qu B, Zeng X, Savoie J, Fandrick KR, Desrosiers JN, Tcyrulnikov S, Marsini MA, Buono FG, Li Z, Yang BS, Tang W, Haddad N, Gutierrez O, Wang J, Lee H, Ma S, Campbell S, Lorenz JC, Eckhardt M, Himmelsbach F, Peters S, Patel ND, Tan Z, Yee NK, Song JJ, Roschangar F, Kozlowski MC, Senanayake CH. Wei X, et al. Among authors: patel nd. J Am Chem Soc. 2016 Nov 30;138(47):15473-15481. doi: 10.1021/jacs.6b09764. Epub 2016 Nov 17. J Am Chem Soc. 2016. PMID: 27794616 Free PMC article.
Efficient asymmetric synthesis of structurally diverse P-stereogenic phosphinamides for catalyst design.
Han ZS, Zhang L, Xu Y, Sieber JD, Marsini MA, Li Z, Reeves JT, Fandrick KR, Patel ND, Desrosiers JN, Qu B, Chen A, Rudzinski DM, Samankumara LP, Ma S, Grinberg N, Roschangar F, Yee NK, Wang G, Song JJ, Senanayake CH. Han ZS, et al. Among authors: patel nd. Angew Chem Int Ed Engl. 2015 Apr 27;54(18):5474-7. doi: 10.1002/anie.201500350. Epub 2015 Mar 10. Angew Chem Int Ed Engl. 2015. PMID: 25757595
One-pot synthesis of 2,5-disubstituted pyrimidines from nitriles.
Frutos RP, Wei X, Patel ND, Tampone TG, Mulder JA, Busacca CA, Senanayake CH. Frutos RP, et al. Among authors: patel nd. J Org Chem. 2013 Jun 7;78(11):5800-3. doi: 10.1021/jo400720p. Epub 2013 May 22. J Org Chem. 2013. PMID: 23656541
348 results