Leusen JHW - Search Results

1

IgA-Mediated Killing of Tumor Cells by Neutrophils Is Enhanced by CD47-SIRPα Checkpoint Inhibition.

Treffers LW, Ten Broeke T, Rösner T, Jansen JHM, van Houdt M, Kahle S, Schornagel K, Verkuijlen PJJH, Prins JM, Franke K, Kuijpers TW, van den Berg TK, Valerius T, Leusen JHW, Matlung HL. Treffers LW, et al. Among authors: leusen jhw. Cancer Immunol Res. 2020 Jan;8(1):120-130. doi: 10.1158/2326-6066.CIR-19-0144. Epub 2019 Nov 5. Cancer Immunol Res. 2020. PMID: 31690649

2

Cytolytic mechanisms and expression of activation-regulating receptors on effector-type CD8+CD45RA+CD27- human T cells.

Baars PA, Ribeiro Do Couto LM, Leusen JH, Hooibrink B, Kuijpers TW, Lens SM, van Lier RA. Baars PA, et al. J Immunol. 2000 Aug 15;165(4):1910-7. doi: 10.4049/jimmunol.165.4.1910. J Immunol. 2000. PMID: 10925272

3

The high-affinity IgG receptor, FcgammaRI, plays a central role in antibody therapy of experimental melanoma.

Bevaart L, Jansen MJ, van Vugt MJ, Verbeek JS, van de Winkel JG, Leusen JH. Bevaart L, et al. Cancer Res. 2006 Feb 1;66(3):1261-4. doi: 10.1158/0008-5472.CAN-05-2856. Cancer Res. 2006. PMID: 16452176

4

FcR gamma-chain dependent signaling in immature neutrophils is mediated by FcalphaRI, but not by FcgammaRI.

Otten MA, Leusen JH, Rudolph E, van der Linden JA, Beelen RH, van de Winkel JG, van Egmond M. Otten MA, et al. J Immunol. 2007 Sep 1;179(5):2918-24. doi: 10.4049/jimmunol.179.5.2918. J Immunol. 2007. PMID: 17709506

5

In vivo cytotoxicity of type I CD20 antibodies critically depends on Fc receptor ITAM signaling.

de Haij S, Jansen JH, Boross P, Beurskens FJ, Bakema JE, Bos DL, Martens A, Verbeek JS, Parren PW, van de Winkel JG, Leusen JH. de Haij S, et al. Cancer Res. 2010 Apr 15;70(8):3209-17. doi: 10.1158/0008-5472.CAN-09-4109. Epub 2010 Mar 30. Cancer Res. 2010. PMID: 20354182

6

Recombinant dimeric IgA antibodies against the epidermal growth factor receptor mediate effective tumor cell killing.

Lohse S, Derer S, Beyer T, Klausz K, Peipp M, Leusen JH, van de Winkel JG, Dechant M, Valerius T. Lohse S, et al. J Immunol. 2011 Mar 15;186(6):3770-8. doi: 10.4049/jimmunol.1003082. Epub 2011 Feb 11. J Immunol. 2011. PMID: 21317397

7

The in vivo mechanism of action of CD20 monoclonal antibodies depends on local tumor burden.

Boross P, Jansen JH, de Haij S, Beurskens FJ, van der Poel CE, Bevaart L, Nederend M, Golay J, van de Winkel JG, Parren PW, Leusen JH. Boross P, et al. Haematologica. 2011 Dec;96(12):1822-30. doi: 10.3324/haematol.2011.047159. Epub 2011 Aug 31. Haematologica. 2011. PMID: 21880632 Free PMC article.

8

Both activating and inhibitory Fc gamma receptors mediate rituximab-induced trogocytosis of CD20 in mice.

Boross P, Jansen JH, Pastula A, van der Poel CE, Leusen JH. Boross P, et al. Immunol Lett. 2012 Mar 30;143(1):44-52. doi: 10.1016/j.imlet.2012.01.004. Epub 2012 Jan 23. Immunol Lett. 2012. PMID: 22285696

9

Characterization of a mutated IgA2 antibody of the m(1) allotype against the epidermal growth factor receptor for the recruitment of monocytes and macrophages.

Lohse S, Brunke C, Derer S, Peipp M, Boross P, Kellner C, Beyer T, Dechant M, van der Winkel JG, Leusen JH, Valerius T. Lohse S, et al. J Biol Chem. 2012 Jul 20;287(30):25139-50. doi: 10.1074/jbc.M112.353060. Epub 2012 Jun 7. J Biol Chem. 2012. PMID: 22679018 Free PMC article.

10

Crosstalk between human IgG isotypes and murine effector cells.

Overdijk MB, Verploegen S, Ortiz Buijsse A, Vink T, Leusen JH, Bleeker WK, Parren PW. Overdijk MB, et al. J Immunol. 2012 Oct 1;189(7):3430-8. doi: 10.4049/jimmunol.1200356. Epub 2012 Sep 5. J Immunol. 2012. PMID: 22956577

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