Debler EW - Search Results

1

Structural Basis of Protein Arginine Methyltransferase Activation by a Catalytically Dead Homolog (Prozyme).

Hashimoto H, Kafková L, Raczkowski A, Jordan KD, Read LK, Debler EW. Hashimoto H, et al. Among authors: debler ew. J Mol Biol. 2020 Jan 17;432(2):410-426. doi: 10.1016/j.jmb.2019.11.002. Epub 2019 Nov 11. J Mol Biol. 2020. PMID: 31726063 Free PMC article.

2

A glutamate/aspartate switch controls product specificity in a protein arginine methyltransferase.

Debler EW, Jain K, Warmack RA, Feng Y, Clarke SG, Blobel G, Stavropoulos P. Debler EW, et al. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2068-73. doi: 10.1073/pnas.1525783113. Epub 2016 Feb 8. Proc Natl Acad Sci U S A. 2016. PMID: 26858449 Free PMC article.

3

Protein Arginine Methyltransferase Product Specificity Is Mediated by Distinct Active-site Architectures.

Jain K, Warmack RA, Debler EW, Hadjikyriacou A, Stavropoulos P, Clarke SG. Jain K, et al. Among authors: debler ew. J Biol Chem. 2016 Aug 26;291(35):18299-308. doi: 10.1074/jbc.M116.740399. Epub 2016 Jul 7. J Biol Chem. 2016. PMID: 27387499 Free PMC article.

4

The Major Protein Arginine Methyltransferase in Trypanosoma brucei Functions as an Enzyme-Prozyme Complex.

Kafková L, Debler EW, Fisk JC, Jain K, Clarke SG, Read LK. Kafková L, et al. Among authors: debler ew. J Biol Chem. 2017 Feb 10;292(6):2089-2100. doi: 10.1074/jbc.M116.757112. Epub 2016 Dec 20. J Biol Chem. 2017. PMID: 27998975 Free PMC article.

5

Trypanosoma brucei PRMT1 Is a Nucleic Acid Binding Protein with a Role in Energy Metabolism and the Starvation Stress Response.

Kafková L, Tu C, Pazzo KL, Smith KP, Debler EW, Paul KS, Qu J, Read LK. Kafková L, et al. Among authors: debler ew. mBio. 2018 Dec 18;9(6):e02430-18. doi: 10.1128/mBio.02430-18. mBio. 2018. PMID: 30563898 Free PMC article.

6

Substrate Affinity and Specificity of the ScSth1p Bromodomain Are Fine-Tuned for Versatile Histone Recognition.

Blus BJ, Hashimoto H, Seo HS, Krolak A, Debler EW. Blus BJ, et al. Among authors: debler ew. Structure. 2019 Sep 3;27(9):1460-1468.e3. doi: 10.1016/j.str.2019.06.009. Epub 2019 Jul 18. Structure. 2019. PMID: 31327661 Free article.

7

Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates.

Farkas M, Hashimoto H, Bi Y, Davuluri RV, Resnick-Silverman L, Manfredi JJ, Debler EW, McMahon SB. Farkas M, et al. Among authors: debler ew. Nat Commun. 2021 Jan 20;12(1):484. doi: 10.1038/s41467-020-20783-z. Nat Commun. 2021. PMID: 33473123 Free PMC article.

8

Structure of the pre-mRNA leakage 39-kDa protein reveals a single domain of integrated zf-C3HC and Rsm1 modules.

Hashimoto H, Ramirez DH, Lautier O, Pawlak N, Blobel G, Palancade B, Debler EW. Hashimoto H, et al. Among authors: debler ew. Sci Rep. 2022 Oct 21;12(1):17691. doi: 10.1038/s41598-022-22183-3. Sci Rep. 2022. PMID: 36271106 Free PMC article.

9

Two DOT1 enzymes cooperatively mediate efficient ubiquitin-independent histone H3 lysine 76 tri-methylation in kinetoplastids.

Frisbie VS, Hashimoto H, Xie Y, De Luna Vitorino FN, Baeza J, Nguyen T, Yuan Z, Kiselar J, Garcia BA, Debler EW. Frisbie VS, et al. Among authors: debler ew. Nat Commun. 2024 Mar 19;15(1):2467. doi: 10.1038/s41467-024-46637-6. Nat Commun. 2024. PMID: 38503750 Free PMC article.

10

The C-terminal 4CXXC-type zinc finger domain of CDCA7 recognizes hemimethylated DNA and modulates activities of chromatin remodeling enzyme HELLS.

Shinkai A, Hashimoto H, Shimura C, Fujimoto H, Fukuda K, Horikoshi N, Okano M, Niwa H, Debler EW, Kurumizaka H, Shinkai Y. Shinkai A, et al. Among authors: debler ew. Nucleic Acids Res. 2024 Sep 23;52(17):10194-10219. doi: 10.1093/nar/gkae677. Nucleic Acids Res. 2024. PMID: 39142653 Free PMC article.

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