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Page 1
Identification of A Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1.
Beck EM, Parnell E, Cowley A, Porter A, Gillespie J, Robinson J, Robinson L, Pannifer AD, Hamon V, Jones P, Morrison A, McElroy S, Timmerman M, Rutjes H, Mahajan P, Wiejak J, Luchowska-Stańska U, Morgan D, Barker G, Rehmann H, Yarwood SJ. Beck EM, et al. Among authors: luchowska stanska u. Cells. 2019 Nov 12;8(11):1425. doi: 10.3390/cells8111425. Cells. 2019. PMID: 31726720 Free PMC article.
The novel exchange protein activated by cyclic AMP 1 (EPAC1) agonist, I942, regulates inflammatory gene expression in human umbilical vascular endothelial cells (HUVECs).
Wiejak J, van Basten B, Luchowska-Stańska U, Hamilton G, Yarwood SJ. Wiejak J, et al. Among authors: luchowska stanska u. Biochim Biophys Acta Mol Cell Res. 2019 Feb;1866(2):264-276. doi: 10.1016/j.bbamcr.2018.11.004. Epub 2018 Nov 9. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 30414891 Free PMC article.
Selective small-molecule EPAC activators.
Luchowska-Stańska U, Morgan D, Yarwood SJ, Barker G. Luchowska-Stańska U, et al. Biochem Soc Trans. 2019 Oct 31;47(5):1415-1427. doi: 10.1042/BST20190254. Biochem Soc Trans. 2019. PMID: 31671184 Free PMC article. Review.
Mechanism of Action of an EPAC1-Selective Competitive Partial Agonist.
Shao H, Mohamed H, Boulton S, Huang J, Wang P, Chen H, Zhou J, Luchowska-Stańska U, Jentsch NG, Armstrong AL, Magolan J, Yarwood S, Melacini G. Shao H, et al. Among authors: luchowska stanska u. J Med Chem. 2020 May 14;63(9):4762-4775. doi: 10.1021/acs.jmedchem.9b02151. Epub 2020 Apr 16. J Med Chem. 2020. PMID: 32297742