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CLIP-170S is a microtubule +TIP variant that confers resistance to taxanes by impairing drug-target engagement.
Thakkar PV, Kita K, Castillo UD, Galletti G, Madhukar N, Navarro EV, Barasoain I, Goodson HV, Sackett D, Díaz JF, Lu Y, RoyChoudhury A, Molina H, Elemento O, Shah MA, Giannakakou P. Thakkar PV, et al. Dev Cell. 2021 Dec 6;56(23):3264-3275.e7. doi: 10.1016/j.devcel.2021.09.023. Epub 2021 Oct 20. Dev Cell. 2021. PMID: 34672971 Free PMC article.
The Missing Pieces of Artificial Intelligence in Medicine.
Gilvary C, Madhukar N, Elkhader J, Elemento O. Gilvary C, et al. Trends Pharmacol Sci. 2019 Aug;40(8):555-564. doi: 10.1016/j.tips.2019.06.001. Epub 2019 Jul 2. Trends Pharmacol Sci. 2019. PMID: 31277839
Discovery and clinical introduction of first-in-class imipridone ONC201.
Allen JE, Kline CL, Prabhu VV, Wagner J, Ishizawa J, Madhukar N, Lev A, Baumeister M, Zhou L, Lulla A, Stogniew M, Schalop L, Benes C, Kaufman HL, Pottorf RS, Nallaganchu BR, Olson GL, Al-Mulla F, Duvic M, Wu GS, Dicker DT, Talekar MK, Lim B, Elemento O, Oster W, Bertino J, Flaherty K, Wang ML, Borthakur G, Andreeff M, Stein M, El-Deiry WS. Allen JE, et al. Oncotarget. 2016 Nov 8;7(45):74380-74392. doi: 10.18632/oncotarget.11814. Oncotarget. 2016. PMID: 27602582 Free PMC article. Review.
Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia.
Nii T, Prabhu VV, Ruvolo V, Madhukar N, Zhao R, Mu H, Heese L, Nishida Y, Kojima K, Garnett MJ, McDermott U, Benes CH, Charter N, Deacon S, Elemento O, Allen JE, Oster W, Stogniew M, Ishizawa J, Andreeff M. Nii T, et al. Leukemia. 2019 Dec;33(12):2805-2816. doi: 10.1038/s41375-019-0491-z. Epub 2019 May 24. Leukemia. 2019. PMID: 31127149 Free PMC article.
17 results