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Page 1
Ovarian cancer-derived IL-4 promotes immunotherapy resistance.
Mollaoglu G, Tepper A, Falcomatà C, Potak HT, Pia L, Amabile A, Mateus-Tique J, Rabinovich N, Park MD, LaMarche NM, Brody R, Browning L, Lin JR, Zamarin D, Sorger PK, Santagata S, Merad M, Baccarini A, Brown BD. Mollaoglu G, et al. Among authors: brown bd. Cell. 2024 Oct 30:S0092-8674(24)01154-1. doi: 10.1016/j.cell.2024.10.006. Online ahead of print. Cell. 2024. PMID: 39481380
ICOS limits memory-like properties and function of exhausted PD-1 + CD8 T cells.
Humblin E, Korpas I, Prokhnevska N, Vaidya A, Lu J, van der Heide V, Filipescu D, Bobrowski T, Marks A, Park MD, Bernstein E, Brown BD, Lujambio A, Dominguez-Sola D, Rosenberg BR, Kamphorst AO. Humblin E, et al. Among authors: brown bd. bioRxiv [Preprint]. 2024 Sep 20:2024.09.16.611518. doi: 10.1101/2024.09.16.611518. bioRxiv. 2024. PMID: 39345453 Free PMC article. Preprint.
Hematopoietic aging promotes cancer by fueling IL-1⍺-driven emergency myelopoiesis.
Park MD, Le Berichel J, Hamon P, Wilk CM, Belabed M, Yatim N, Saffon A, Boumelha J, Falcomatà C, Tepper A, Hegde S, Mattiuz R, Soong BY, LaMarche NM, Rentzeperis F, Troncoso L, Halasz L, Hennequin C, Chin T, Chen EP, Reid AM, Su M, Cahn AR, Koekkoek LL, Venturini N, Wood-Isenberg S, D'souza D, Chen R, Dawson T, Nie K, Chen Z, Kim-Schulze S, Casanova-Acebes M, Swirski FK, Downward J, Vabret N, Brown BD, Marron TU, Merad M. Park MD, et al. Among authors: brown bd. Science. 2024 Oct 25;386(6720):eadn0327. doi: 10.1126/science.adn0327. Epub 2024 Oct 25. Science. 2024. PMID: 39236155 Free PMC article.
A STAT3 Degrader Demonstrates Pre-clinical Efficacy in Venetoclax resistant Acute Myeloid Leukemia.
Chakraborty S, Morganti C, Pena BR, Zhang H, Verma D, Zaldana K, Gitego N, Ma F, Aluri S, Pradhan K, Gordon S, Mantzaris I, Goldfinger M, Feldman E, Gritsman K, Shi Y, Hubner S, Qiu YH, Brown BD, Skwarska A, Verma A, Konopleva M, Tabe Y, Gavathiotis E, Colla S, Gollob J, Dey J, Kornblau SM, Koralov SB, Ito K, Shastri A. Chakraborty S, et al. Among authors: brown bd. bioRxiv [Preprint]. 2024 Aug 7:2024.08.05.599788. doi: 10.1101/2024.08.05.599788. bioRxiv. 2024. PMID: 39211137 Free PMC article. Preprint.
Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes.
You Y, Dunst J, Ye K, Sandoz PA, Reinhardt A, Sandrock I, Comet NR, Sarkar RD, Yang E, Duprez E, Agudo J, Brown BD, Utz PJ, Kastenmüller W, Gerlach C, Prinz I, Önfelt B, Kreslavsky T. You Y, et al. Among authors: brown bd. Nat Immunol. 2024 Aug;25(8):1367-1382. doi: 10.1038/s41590-024-01899-6. Epub 2024 Jul 11. Nat Immunol. 2024. PMID: 38992254 Free PMC article.
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumors.
Hegde S, Giotti B, Soong BY, Halasz L, Berichel JL, Magen A, Kloeckner B, Mattiuz R, Park MD, Marks A, Belabed M, Hamon P, Chin T, Troncoso L, Lee JJ, Ahimovic D, Bale M, Chung G, D'souza D, Angeliadis K, Dawson T, Kim-Schulze S, Flores RM, Kaufman AJ, Ginhoux F, Josefowicz SZ, Ma S, Tsankov AM, Marron TU, Brown BD, Merad M. Hegde S, et al. Among authors: brown bd. bioRxiv [Preprint]. 2024 Jun 28:2024.06.24.600383. doi: 10.1101/2024.06.24.600383. bioRxiv. 2024. PMID: 38979166 Free PMC article. Preprint.
The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program.
Burton OT, Bricard O, Tareen S, Gergelits V, Andrews S, Biggins L, Roca CP, Whyte C, Junius S, Brajic A, Pasciuto E, Ali M, Lemaitre P, Schlenner SM, Ishigame H, Brown BD, Dooley J, Liston A. Burton OT, et al. Among authors: brown bd. Immunity. 2024 Jul 9;57(7):1586-1602.e10. doi: 10.1016/j.immuni.2024.05.023. Epub 2024 Jun 18. Immunity. 2024. PMID: 38897202 Free article.
194 results