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The growth of a xenograft breast cancer tumor model with engineered hyaluronan-accumulating stroma is dependent on hyaluronan and independent of CD44.
Zhao C, Thompson BJ, Chen K, Gao F, Blouw B, Marella M, Zimmerman S, Kimbler T, Garrovillo S, Bahn J, Huang L, Huang Z, Shepard HM, Rosengren S, Thanos CD, Maneval DC. Zhao C, et al. Among authors: huang l, huang z. Oncotarget. 2019 Nov 12;10(61):6561-6576. doi: 10.18632/oncotarget.27302. eCollection 2019 Nov 12. Oncotarget. 2019. PMID: 31762938 Free PMC article.
Recombinant human hyaluronidase PH20 does not stimulate an acute inflammatory response and inhibits lipopolysaccharide-induced neutrophil recruitment in the air pouch model of inflammation.
Huang Z, Zhao C, Chen Y, Cowell JA, Wei G, Kultti A, Huang L, Thompson CB, Rosengren S, Frost GI, Shepard HM. Huang Z, et al. Among authors: huang l. J Immunol. 2014 Jun 1;192(11):5285-95. doi: 10.4049/jimmunol.1303060. Epub 2014 Apr 28. J Immunol. 2014. PMID: 24778442
PH20 is not expressed in murine CNS and oligodendrocyte precursor cells.
Marella M, Ouyang J, Zombeck J, Zhao C, Huang L, Connor RJ, Phan KB, Jorge MC, Printz MA, Paladini RD, Gelb AB, Huang Z, Frost GI, Sugarman BJ, Steinman L, Wei G, Shepard HM, Maneval DC, Lapinskas PJ. Marella M, et al. Among authors: huang l, huang z. Ann Clin Transl Neurol. 2017 Feb 23;4(3):191-211. doi: 10.1002/acn3.393. eCollection 2017 Mar. Ann Clin Transl Neurol. 2017. PMID: 28275653 Free PMC article.
Targeting Adenosine with Adenosine Deaminase 2 to Inhibit Growth of Solid Tumors.
Wang L, Londono LM, Cowell J, Saatci O, Aras M, Ersan PG, Serra S, Pei H, Clift R, Zhao Q, Phan KB, Huang L, LaBarre MJ, Li X, Shepard HM, Deaglio S, Linden J, Thanos CD, Sahin O, Cekic C. Wang L, et al. Among authors: huang l. Cancer Res. 2021 Jun 15;81(12):3319-3332. doi: 10.1158/0008-5472.CAN-21-0340. Epub 2021 Apr 16. Cancer Res. 2021. PMID: 33863778
Targeting GSDMD JX06 inhibits PANoptosis and multiple organ injury.
Chen S, Wu G, Li T, Jiang J, Zhong Y, Sun D, Qian F, Huang LS. Chen S, et al. Among authors: huang ls. Biochem Pharmacol. 2025 Jan 21:116765. doi: 10.1016/j.bcp.2025.116765. Online ahead of print. Biochem Pharmacol. 2025. PMID: 39848475
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