Ocasio CA - Search Results

1

Acylation-coupled lipophilic induction of polarisation (Acyl-cLIP): a universal assay for lipid transferase and hydrolase enzymes.

Lanyon-Hogg T, Ritzefeld M, Sefer L, Bickel JK, Rudolf AF, Panyain N, Bineva-Todd G, Ocasio CA, O'Reilly N, Siebold C, Magee AI, Tate EW. Lanyon-Hogg T, et al. Among authors: ocasio ca. Chem Sci. 2019 Jul 1;10(39):8995-9000. doi: 10.1039/c9sc01785b. eCollection 2019 Oct 21. Chem Sci. 2019. PMID: 31762980 Free PMC article.

2

Wheat pathogen Zymoseptoria tritici N-myristoyltransferase inhibitors: on-target antifungal activity and an unusual metabolic defense mechanism.

Fedoryshchak RO, Ocasio CA, Strutton B, Mattocks J, Corran AJ, Tate EW. Fedoryshchak RO, et al. Among authors: ocasio ca. RSC Chem Biol. 2020 May 13;1(2):68-78. doi: 10.1039/d0cb00020e. eCollection 2020 Jun 1. RSC Chem Biol. 2020. PMID: 34458749 Free PMC article.

3

A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation.

Ocasio CA, Baggelaar MP, Sipthorp J, Losada de la Lastra A, Tavares M, Volarić J, Soudy C, Storck EM, Houghton JW, Palma-Duran SA, MacRae JI, Tomić G, Carr L, Downward J, Eggert US, Tate EW. Ocasio CA, et al. Nat Biotechnol. 2024 Oct;42(10):1548-1558. doi: 10.1038/s41587-023-02030-0. Epub 2024 Jan 8. Nat Biotechnol. 2024. PMID: 38191663 Free PMC article.

4

Type II Kinase Inhibitors Targeting Cys-Gatekeeper Kinases Display Orthogonality with Wild Type and Ala/Gly-Gatekeeper Kinases.

Ocasio CA, Warkentin AA, McIntyre PJ, Barkovich KJ, Vesely C, Spencer J, Shokat KM, Bayliss R. Ocasio CA, et al. ACS Chem Biol. 2018 Oct 19;13(10):2956-2965. doi: 10.1021/acschembio.8b00592. Epub 2018 Oct 9. ACS Chem Biol. 2018. PMID: 30239186 Free article.

5

Design and characterization of a thyroid hormone receptor alpha (TRalpha)-specific agonist.

Ocasio CA, Scanlan TS. Ocasio CA, et al. ACS Chem Biol. 2006 Oct 24;1(9):585-93. doi: 10.1021/cb600311v. ACS Chem Biol. 2006. PMID: 17168554

6

PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit.

Hégarat N, Vesely C, Vinod PK, Ocasio C, Peter N, Gannon J, Oliver AW, Novák B, Hochegger H. Hégarat N, et al. PLoS Genet. 2014 Jan;10(1):e1004004. doi: 10.1371/journal.pgen.1004004. Epub 2014 Jan 2. PLoS Genet. 2014. PMID: 24391510 Free PMC article.

7

Elaboration of tetra-orthogonally-substituted aromatic scaffolds towards novel EGFR-kinase inhibitors.

Close AJ, Jones RN, Ocasio CA, Kemmitt P, Roe SM, Spencer J. Close AJ, et al. Among authors: ocasio ca. Org Biomol Chem. 2016 Sep 21;14(35):8246-52. doi: 10.1039/c6ob01394e. Epub 2016 Jul 25. Org Biomol Chem. 2016. PMID: 27453149

8

A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct.

Ocasio CA, Rajasekaran MB, Walker S, Le Grand D, Spencer J, Pearl FM, Ward SE, Savic V, Pearl LH, Hochegger H, Oliver AW. Ocasio CA, et al. Oncotarget. 2016 Nov 1;7(44):71182-71197. doi: 10.18632/oncotarget.11511. Oncotarget. 2016. PMID: 27563826 Free PMC article.

9

Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety.

Sansook S, Ocasio CA, Day IJ, Tizzard GJ, Coles SJ, Fedorov O, Bennett JM, Elkins JM, Spencer J. Sansook S, et al. Among authors: ocasio ca. Org Biomol Chem. 2017 Oct 18;15(40):8655-8660. doi: 10.1039/c7ob02289a. Org Biomol Chem. 2017. PMID: 28984325 Free PMC article.

10

Correction: Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety.

Sansook S, Ocasio CA, Day IJ, Tizzard GJ, Coles SJ, Fedorov O, Bennett JM, Elkins JM, Spencer J. Sansook S, et al. Among authors: ocasio ca. Org Biomol Chem. 2018 Jan 3;16(2):336. doi: 10.1039/c7ob90195j. Org Biomol Chem. 2018. PMID: 29256564 Free PMC article.

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