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Non-enzymatic Lysine Lactoylation of Glycolytic Enzymes.
Gaffney DO, Jennings EQ, Anderson CC, Marentette JO, Shi T, Schou Oxvig AM, Streeter MD, Johannsen M, Spiegel DA, Chapman E, Roede JR, Galligan JJ. Gaffney DO, et al. Among authors: shi t. Cell Chem Biol. 2020 Feb 20;27(2):206-213.e6. doi: 10.1016/j.chembiol.2019.11.005. Epub 2019 Nov 22. Cell Chem Biol. 2020. PMID: 31767537 Free PMC article.
Selective inhibition of p97 by chlorinated analogues of dehydrocurvularin.
Tillotson J, Bashyal BP, Kang M, Shi T, De La Cruz F, Gunatilaka AA, Chapman E. Tillotson J, et al. Among authors: shi t. Org Biomol Chem. 2016 Jul 7;14(25):5918-21. doi: 10.1039/c6ob00560h. Epub 2016 May 25. Org Biomol Chem. 2016. PMID: 27223265 Free PMC article.
An epigenetic modifier induces production of (10'S)-verruculide B, an inhibitor of protein tyrosine phosphatases by Phoma sp. nov. LG0217, a fungal endophyte of Parkinsonia microphylla.
Gubiani JR, Wijeratne EM, Shi T, Araujo AR, Arnold AE, Chapman E, Gunatilaka AA. Gubiani JR, et al. Among authors: shi t. Bioorg Med Chem. 2017 Mar 15;25(6):1860-1866. doi: 10.1016/j.bmc.2017.01.048. Epub 2017 Feb 3. Bioorg Med Chem. 2017. PMID: 28202316 Free PMC article.
An Isoform-Selective PTP1B Inhibitor Derived from Nitrogen-Atom Augmentation of Radicicol.
Shi T, Wijeratne EMK, Solano C, Ambrose AJ, Ross AB, Norwood C, Orido CK, Grigoryan T, Tillotson J, Kang M, Luo G, Keegan BM, Hu W, Blagg BSJ, Zhang DD, Gunatilaka AAL, Chapman E. Shi T, et al. Biochemistry. 2019 Jul 30;58(30):3225-3231. doi: 10.1021/acs.biochem.9b00499. Epub 2019 Jul 18. Biochemistry. 2019. PMID: 31298844 Free PMC article.
Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action.
Zerio CJ, Cunningham TA, Tulino AS, Alimusa EA, Buckley TM, Moore KT, Dodson M, Wilson NC, Ambrose AJ, Shi T, Sivinski J, Essegian DJ, Zhang DD, Schürer SC, Schatz JH, Chapman E. Zerio CJ, et al. Among authors: shi t. J Med Chem. 2021 Nov 11;64(21):15727-15746. doi: 10.1021/acs.jmedchem.1c01014. Epub 2021 Oct 22. J Med Chem. 2021. PMID: 34676755 Free PMC article.
3,714 results