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Activity of the Ste20-like kinase, SLK, is enhanced by homodimerization.
Delarosa S, Guillemette J, Papillon J, Han YS, Kristof AS, Cybulsky AV. Delarosa S, et al. Am J Physiol Renal Physiol. 2011 Sep;301(3):F554-64. doi: 10.1152/ajprenal.00062.2011. Epub 2011 Jun 15. Am J Physiol Renal Physiol. 2011. PMID: 21677149 Free PMC article.
Addition of E138K to R263K in HIV integrase increases resistance to dolutegravir, but fails to restore activity of the HIV integrase enzyme and viral replication capacity.
Mesplède T, Osman N, Wares M, Quashie PK, Hassounah S, Anstett K, Han Y, Singhroy DN, Wainberg MA. Mesplède T, et al. Among authors: han y. J Antimicrob Chemother. 2014 Oct;69(10):2733-40. doi: 10.1093/jac/dku199. Epub 2014 Jun 10. J Antimicrob Chemother. 2014. PMID: 24917583 Free PMC article.
The connection domain mutation N348I in HIV-1 reverse transcriptase enhances resistance to etravirine and rilpivirine but restricts the emergence of the E138K resistance mutation by diminishing viral replication capacity.
Xu HT, Colby-Germinario SP, Oliveira M, Han Y, Quan Y, Zanichelli V, Wainberg MA. Xu HT, et al. Among authors: han y. J Virol. 2014 Feb;88(3):1536-47. doi: 10.1128/JVI.02904-13. Epub 2013 Nov 13. J Virol. 2014. PMID: 24227862 Free PMC article.
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