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Discovery of HZS60 as a Novel Brain Penetrant NMDAR/TRPM4 Interaction Interface Inhibitor with Improved Activity and Pharmacokinetic Properties for the Treatment of Cerebral Ischemia.
Sun M, Wang L, Cao Q, Wang X, Zhang Y, Guo M, Chen J, Ma Y, Niu L, Zhang Y, Hu M, Gu M, Zhu Z, Yao X, Yao J, Zhao C, Wu J, Liu X, Lu Y, Wang Z, Xiang Q, Han F, Zhu D. Sun M, et al. Among authors: wang x. J Med Chem. 2025 Jan 2. doi: 10.1021/acs.jmedchem.4c02772. Online ahead of print. J Med Chem. 2025. PMID: 39745498
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