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Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell.
He Y, Schreiber K, Wolf SP, Wen F, Steentoft C, Zerweck J, Steiner M, Sharma P, Shepard HM, Posey A, June CH, Mandel U, Clausen H, Leisegang M, Meredith SC, Kranz DM, Schreiber H. He Y, et al. Among authors: posey a. JCI Insight. 2019 Dec 5;4(23):e135306. doi: 10.1172/jci.insight.135306. JCI Insight. 2019. PMID: 31801912 Free PMC article. No abstract available.
Measurement of intracellular ions by flow cytometry.
Posey AD Jr, Kawalekar OU, June CH. Posey AD Jr, et al. Curr Protoc Cytom. 2015 Apr 1;72:9.8.1-9.8.21. doi: 10.1002/0471142956.cy0908s72. Curr Protoc Cytom. 2015. PMID: 25827486
Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma.
Posey AD Jr, Schwab RD, Boesteanu AC, Steentoft C, Mandel U, Engels B, Stone JD, Madsen TD, Schreiber K, Haines KM, Cogdill AP, Chen TJ, Song D, Scholler J, Kranz DM, Feldman MD, Young R, Keith B, Schreiber H, Clausen H, Johnson LA, June CH. Posey AD Jr, et al. Immunity. 2016 Jun 21;44(6):1444-54. doi: 10.1016/j.immuni.2016.05.014. Immunity. 2016. PMID: 27332733 Free PMC article.
Distinguishing Truncated and Normal MUC1 Glycoform Targeting from Tn-MUC1-Specific CAR T Cells: Specificity Is the Key to Safety.
Posey AD Jr, Clausen H, June CH. Posey AD Jr, et al. Immunity. 2016 Nov 15;45(5):947-948. doi: 10.1016/j.immuni.2016.10.015. Immunity. 2016. PMID: 27851918 Free article.
Genetically modified T cells expressing chimeric antigen receptors (CARs) demonstrate potent clinical antitumor effects in a variety of blood cancers. However, clinical activity in solid tumors has been disappointing and toxicity has been a serious concern (Lamers e …
Genetically modified T cells expressing chimeric antigen receptors (CARs) demonstrate potent clinical antitumor effects in a variety …
Cancer Killers.
Posey AD Jr, June CH, Levine BL. Posey AD Jr, et al. Sci Am. 2017 Feb 14;316(3):38-43. doi: 10.1038/scientificamerican0317-38. Sci Am. 2017. PMID: 28207696 No abstract available.
Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation.
Guedan S, Posey AD Jr, Shaw C, Wing A, Da T, Patel PR, McGettigan SE, Casado-Medrano V, Kawalekar OU, Uribe-Herranz M, Song D, Melenhorst JJ, Lacey SF, Scholler J, Keith B, Young RM, June CH. Guedan S, et al. Among authors: posey ad jr. JCI Insight. 2018 Jan 11;3(1):e96976. doi: 10.1172/jci.insight.96976. eCollection 2018 Jan 11. JCI Insight. 2018. PMID: 29321369 Free PMC article.
Glycan-directed CAR-T cells.
Steentoft C, Migliorini D, King TR, Mandel U, June CH, Posey AD Jr. Steentoft C, et al. Glycobiology. 2018 Sep 1;28(9):656-669. doi: 10.1093/glycob/cwy008. Glycobiology. 2018. PMID: 29370379 Review.
87 results