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PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours.
Wiede F, Lu KH, Du X, Liang S, Hochheiser K, Dodd GT, Goh PK, Kearney C, Meyran D, Beavis PA, Henderson MA, Park SL, Waithman J, Zhang S, Zhang ZY, Oliaro J, Gebhardt T, Darcy PK, Tiganis T. Wiede F, et al. Among authors: park sl. EMBO J. 2020 Jan 15;39(2):e103637. doi: 10.15252/embj.2019103637. Epub 2019 Dec 5. EMBO J. 2020. PMID: 31803974 Free PMC article.
Tissue-resident memory CD8+ T cells promote melanoma-immune equilibrium in skin.
Park SL, Buzzai A, Rautela J, Hor JL, Hochheiser K, Effern M, McBain N, Wagner T, Edwards J, McConville R, Wilmott JS, Scolyer RA, Tüting T, Palendira U, Gyorki D, Mueller SN, Huntington ND, Bedoui S, Hölzel M, Mackay LK, Waithman J, Gebhardt T. Park SL, et al. Nature. 2019 Jan;565(7739):366-371. doi: 10.1038/s41586-018-0812-9. Epub 2018 Dec 31. Nature. 2019. PMID: 30598548
Tissue-resident memory T cells orchestrate tumour-immune equilibrium.
Park SL, Mackay LK, Waithman J, Gebhardt T. Park SL, et al. Cell Stress. 2019 Apr 26;3(5):162-164. doi: 10.15698/cst2019.05.187. Cell Stress. 2019. PMID: 31225511 Free PMC article.
However, the mechanisms through which these cells mediate cancer protection are poorly understood. In our recent study (Park SL et al, Nature 565(7739), 2019) we developed a melanoma model that allowed us to identify a critical role for T(RM) cells in the establishm …
However, the mechanisms through which these cells mediate cancer protection are poorly understood. In our recent study (Park SL …
Ptpn2 and KLRG1 regulate the generation and function of tissue-resident memory CD8+ T cells in skin.
Hochheiser K, Wiede F, Wagner T, Freestone D, Enders MH, Olshansky M, Russ B, Nüssing S, Bawden E, Braun A, Bachem A, Gressier E, McConville R, Park SL, Jones CM, Davey GM, Gyorki DE, Tscharke D, Parish IA, Turner S, Herold MJ, Tiganis T, Bedoui S, Gebhardt T. Hochheiser K, et al. Among authors: park sl. J Exp Med. 2021 Jun 7;218(6):e20200940. doi: 10.1084/jem.20200940. J Exp Med. 2021. PMID: 33914023 Free PMC article.
Single-cell protein expression profiling resolves circulating and resident memory T cell diversity across tissues and infection contexts.
Evrard M, Becht E, Fonseca R, Obers A, Park SL, Ghabdan-Zanluqui N, Schroeder J, Christo SN, Schienstock D, Lai J, Burn TN, Clatch A, House IG, Beavis P, Kallies A, Ginhoux F, Mueller SN, Gottardo R, Newell EW, Mackay LK. Evrard M, et al. Among authors: park sl. Immunity. 2023 Jul 11;56(7):1664-1680.e9. doi: 10.1016/j.immuni.2023.06.005. Epub 2023 Jun 30. Immunity. 2023. PMID: 37392736 Free article.
Stem-like exhausted and memory CD8+ T cells in cancer.
Gebhardt T, Park SL, Parish IA. Gebhardt T, et al. Among authors: park sl. Nat Rev Cancer. 2023 Nov;23(11):780-798. doi: 10.1038/s41568-023-00615-0. Epub 2023 Oct 11. Nat Rev Cancer. 2023. PMID: 37821656 Review.
206 results