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Page 1
IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis.
Lückel C, Picard F, Raifer H, Campos Carrascosa L, Guralnik A, Zhang Y, Klein M, Bittner S, Steffen F, Moos S, Marini F, Gloury R, Kurschus FC, Chao YY, Bertrams W, Sexl V, Schmeck B, Bonetti L, Grusdat M, Lohoff M, Zielinski CE, Zipp F, Kallies A, Brenner D, Berger M, Bopp T, Tackenberg B, Huber M. Lückel C, et al. Among authors: grusdat m. Nat Commun. 2019 Dec 16;10(1):5722. doi: 10.1038/s41467-019-13731-z. Nat Commun. 2019. PMID: 31844089 Free PMC article.
The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells.
Raczkowski F, Ritter J, Heesch K, Schumacher V, Guralnik A, Höcker L, Raifer H, Klein M, Bopp T, Harb H, Kesper DA, Pfefferle PI, Grusdat M, Lang PA, Mittrücker HW, Huber M. Raczkowski F, et al. Among authors: grusdat m. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15019-24. doi: 10.1073/pnas.1309378110. Epub 2013 Aug 26. Proc Natl Acad Sci U S A. 2013. PMID: 23980171 Free PMC article.
IRF4 and BATF are critical for CD8⁺ T-cell function following infection with LCMV.
Grusdat M, McIlwain DR, Xu HC, Pozdeev VI, Knievel J, Crome SQ, Robert-Tissot C, Dress RJ, Pandyra AA, Speiser DE, Lang E, Maney SK, Elford AR, Hamilton SR, Scheu S, Pfeffer K, Bode J, Mittrücker HW, Lohoff M, Huber M, Häussinger D, Ohashi PS, Mak TW, Lang KS, Lang PA. Grusdat M, et al. Cell Death Differ. 2014 Jul;21(7):1050-60. doi: 10.1038/cdd.2014.19. Epub 2014 Feb 14. Cell Death Differ. 2014. PMID: 24531538 Free PMC article.
Glutathione Primes T Cell Metabolism for Inflammation.
Mak TW, Grusdat M, Duncan GS, Dostert C, Nonnenmacher Y, Cox M, Binsfeld C, Hao Z, Brüstle A, Itsumi M, Jäger C, Chen Y, Pinkenburg O, Camara B, Ollert M, Bindslev-Jensen C, Vasiliou V, Gorrini C, Lang PA, Lohoff M, Harris IS, Hiller K, Brenner D. Mak TW, et al. Among authors: grusdat m. Immunity. 2017 Apr 18;46(4):675-689. doi: 10.1016/j.immuni.2017.03.019. Immunity. 2017. PMID: 28423341 Free article.
B-Cell Metabolic Remodeling and Cancer.
Franchina DG, Grusdat M, Brenner D. Franchina DG, et al. Among authors: grusdat m. Trends Cancer. 2018 Feb;4(2):138-150. doi: 10.1016/j.trecan.2017.12.006. Epub 2018 Feb 1. Trends Cancer. 2018. PMID: 29458963 Review.
Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function.
Kurniawan H, Franchina DG, Guerra L, Bonetti L, -Baguet LS, Grusdat M, Schlicker L, Hunewald O, Dostert C, Merz MP, Binsfeld C, Duncan GS, Farinelle S, Nonnenmacher Y, Haight J, Das Gupta D, Ewen A, Taskesen R, Halder R, Chen Y, Jäger C, Ollert M, Wilmes P, Vasiliou V, Harris IS, Knobbe-Thomsen CB, Turner JD, Mak TW, Lohoff M, Meiser J, Hiller K, Brenner D. Kurniawan H, et al. Among authors: grusdat m. Cell Metab. 2020 May 5;31(5):920-936.e7. doi: 10.1016/j.cmet.2020.03.004. Epub 2020 Mar 25. Cell Metab. 2020. PMID: 32213345 Free PMC article.
Glutathione-dependent redox balance characterizes the distinct metabolic properties of follicular and marginal zone B cells.
Franchina DG, Kurniawan H, Grusdat M, Binsfeld C, Guerra L, Bonetti L, Soriano-Baguet L, Ewen A, Kobayashi T, Farinelle S, Minafra AR, Vandamme N, Carpentier A, Borgmann FK, Jäger C, Chen Y, Kleinewietfeld M, Vasiliou V, Mittelbronn M, Hiller K, Lang PA, Brenner D. Franchina DG, et al. Among authors: grusdat m. Nat Commun. 2022 Apr 4;13(1):1789. doi: 10.1038/s41467-022-29426-x. Nat Commun. 2022. PMID: 35379825 Free PMC article.
PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains Treg homeostasis during ageing.
Danileviciute E, Zeng N, Capelle CM, Paczia N, Gillespie MA, Kurniawan H, Benzarti M, Merz MP, Coowar D, Fritah S, Vogt Weisenhorn DM, Gomez Giro G, Grusdat M, Baron A, Guerin C, Franchina DG, Léonard C, Domingues O, Delhalle S, Wurst W, Turner JD, Schwamborn JC, Meiser J, Krüger R, Ranish J, Brenner D, Linster CL, Balling R, Ollert M, Hefeng FQ. Danileviciute E, et al. Among authors: grusdat m. Nat Metab. 2022 May;4(5):589-607. doi: 10.1038/s42255-022-00576-y. Epub 2022 May 26. Nat Metab. 2022. PMID: 35618940
Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages.
He W, Henne A, Lauterbach M, Geißmar E, Nikolka F, Kho C, Heinz A, Dostert C, Grusdat M, Cordes T, Härm J, Goldmann O, Ewen A, Verschueren C, Blay-Cadanet J, Geffers R, Garritsen H, Kneiling M, Holm CK, Metallo CM, Medina E, Abdullah Z, Latz E, Brenner D, Hiller K. He W, et al. Among authors: grusdat m. Nat Metab. 2022 May;4(5):524-533. doi: 10.1038/s42255-022-00565-1. Epub 2022 Jun 2. Nat Metab. 2022. PMID: 35655024 Free PMC article.
24 results