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Page 1
IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis.
Lückel C, Picard F, Raifer H, Campos Carrascosa L, Guralnik A, Zhang Y, Klein M, Bittner S, Steffen F, Moos S, Marini F, Gloury R, Kurschus FC, Chao YY, Bertrams W, Sexl V, Schmeck B, Bonetti L, Grusdat M, Lohoff M, Zielinski CE, Zipp F, Kallies A, Brenner D, Berger M, Bopp T, Tackenberg B, Huber M. Lückel C, et al. Among authors: guralnik a. Nat Commun. 2019 Dec 16;10(1):5722. doi: 10.1038/s41467-019-13731-z. Nat Commun. 2019. PMID: 31844089 Free PMC article.
Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4.
Campos Carrascosa L, Klein M, Kitagawa Y, Lückel C, Marini F, König A, Guralnik A, Raifer H, Hagner-Benes S, Rädler D, Böck A, Kang C, Lohoff M, Garn H, Schaub B, Berberich-Siebelt F, Sakaguchi S, Bopp T, Huber M. Campos Carrascosa L, et al. Among authors: guralnik a. Nat Commun. 2017 May 12;8:15366. doi: 10.1038/ncomms15366. Nat Commun. 2017. PMID: 28497800 Free PMC article.
IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis.
Huber M, Heink S, Pagenstecher A, Reinhard K, Ritter J, Visekruna A, Guralnik A, Bollig N, Jeltsch K, Heinemann C, Wittmann E, Buch T, Prazeres da Costa O, Brüstle A, Brenner D, Mak TW, Mittrücker HW, Tackenberg B, Kamradt T, Lohoff M. Huber M, et al. Among authors: guralnik a. J Clin Invest. 2013 Jan;123(1):247-60. doi: 10.1172/JCI63681. Epub 2012 Dec 10. J Clin Invest. 2013. PMID: 23221338 Free PMC article.
Tc9 cells, a new subset of CD8(+) T cells, support Th2-mediated airway inflammation.
Visekruna A, Ritter J, Scholz T, Campos L, Guralnik A, Poncette L, Raifer H, Hagner S, Garn H, Staudt V, Bopp T, Reuter S, Taube C, Loser K, Huber M. Visekruna A, et al. Among authors: guralnik a. Eur J Immunol. 2013 Mar;43(3):606-18. doi: 10.1002/eji.201242825. Epub 2013 Jan 31. Eur J Immunol. 2013. PMID: 23254356 Free article.
The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells.
Raczkowski F, Ritter J, Heesch K, Schumacher V, Guralnik A, Höcker L, Raifer H, Klein M, Bopp T, Harb H, Kesper DA, Pfefferle PI, Grusdat M, Lang PA, Mittrücker HW, Huber M. Raczkowski F, et al. Among authors: guralnik a. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15019-24. doi: 10.1073/pnas.1309378110. Epub 2013 Aug 26. Proc Natl Acad Sci U S A. 2013. PMID: 23980171 Free PMC article.
Unlike αβ T cells, γδ T cells, LTi cells and NKT cells do not require IRF4 for the production of IL-17A and IL-22.
Raifer H, Mahiny AJ, Bollig N, Petermann F, Hellhund A, Kellner K, Guralnik A, Reinhard K, Bothur E, Huber M, Bauer S, Löhning M, Kiss EA, Ganal SC, Diefenbach A, Korn T, Lohoff M. Raifer H, et al. Among authors: guralnik a. Eur J Immunol. 2012 Dec;42(12):3189-201. doi: 10.1002/eji.201142155. Epub 2012 Oct 17. Eur J Immunol. 2012. PMID: 22961652 Free article.
IL-27 inhibits the development of regulatory T cells via STAT3.
Huber M, Steinwald V, Guralnik A, Brüstle A, Kleemann P, Rosenplänter C, Decker T, Lohoff M. Huber M, et al. Among authors: guralnik a. Int Immunol. 2008 Feb;20(2):223-34. doi: 10.1093/intimm/dxm139. Epub 2007 Dec 21. Int Immunol. 2008. PMID: 18156621