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Hypoxia decreases the T helper cell-suppressive capacity of synovial fibroblasts by downregulating IDO1-mediated tryptophan metabolism.
Rheumatology (Oxford). 2020 May 1;59(5):1148-1158. doi: 10.1093/rheumatology/kez587.
Rheumatology (Oxford). 2020.
PMID: 31846032
Synovial Fibroblasts Selectively Suppress Th1 Cell Responses through IDO1-Mediated Tryptophan Catabolism.
Tykocinski LO, Lauffer AM, Bohnen A, Kaul NC, Krienke S, Tretter T, Adam I, Mohapatra SR, Saikali P, Löhning M, Neidhart M, Gay S, Oezen I, Platten M, Opitz CA, Lorenz HM.
Tykocinski LO, et al. Among authors: kaul nc.
J Immunol. 2017 Apr 15;198(8):3109-3117. doi: 10.4049/jimmunol.1600600. Epub 2017 Mar 6.
J Immunol. 2017.
PMID: 28264972
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