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Ultraviolet A light induces DNA damage and estrogen-DNA adducts in Fuchs endothelial corneal dystrophy causing females to be more affected.
Liu C, Miyajima T, Melangath G, Miyai T, Vasanth S, Deshpande N, Kumar V, Ong Tone S, Gupta R, Zhu S, Vojnovic D, Chen Y, Rogan EG, Mondal B, Zahid M, Jurkunas UV. Liu C, et al. Among authors: chen y. Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):573-583. doi: 10.1073/pnas.1912546116. Epub 2019 Dec 18. Proc Natl Acad Sci U S A. 2020. PMID: 31852820 Free PMC article.
NQO1 downregulation potentiates menadione-induced endothelial-mesenchymal transition during rosette formation in Fuchs endothelial corneal dystrophy.
Katikireddy KR, White TL, Miyajima T, Vasanth S, Raoof D, Chen Y, Price MO, Price FW, Jurkunas UV. Katikireddy KR, et al. Among authors: chen y. Free Radic Biol Med. 2018 Feb 20;116:19-30. doi: 10.1016/j.freeradbiomed.2017.12.036. Epub 2017 Dec 30. Free Radic Biol Med. 2018. PMID: 29294389 Free PMC article.
Loss of NQO1 generates genotoxic estrogen-DNA adducts in Fuchs Endothelial Corneal Dystrophy.
Miyajima T, Melangath G, Zhu S, Deshpande N, Vasanth S, Mondal B, Kumar V, Chen Y, Price MO, Price FW Jr, Rogan EG, Zahid M, Jurkunas UV. Miyajima T, et al. Among authors: chen y. Free Radic Biol Med. 2020 Feb 1;147:69-79. doi: 10.1016/j.freeradbiomed.2019.12.014. Epub 2019 Dec 17. Free Radic Biol Med. 2020. PMID: 31857234 Free PMC article.
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