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Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis.
Liu S, González-Prieto R, Zhang M, Geurink PP, Kooij R, Iyengar PV, van Dinther M, Bos E, Zhang X, Le Dévédec SE, van de Water B, Koning RI, Zhu HJ, Mesker WE, Vertegaal ACO, Ovaa H, Zhang L, Martens JWM, Ten Dijke P. Liu S, et al. Among authors: vertegaal aco. Clin Cancer Res. 2020 Mar 15;26(6):1460-1473. doi: 10.1158/1078-0432.CCR-19-1373. Epub 2019 Dec 19. Clin Cancer Res. 2020. PMID: 31857432 Free PMC article.
Exome sequencing links the SUMO protease SENP7 with fatal arthrogryposis multiplex congenita, early respiratory failure and neutropenia.
Samra N, Jansen NS, Morani I, Kakun RR, Zaid R, Paperna T, Garcia-Dominguez M, Viner Y, Frankenthal H, Shinwell ES, Portnov I, Bakry D, Shalata A, Shapira Rootman M, Kidron D, Claessens LA, Wevers RA, Mandel H, Vertegaal ACO, Weiss K. Samra N, et al. Among authors: vertegaal aco. J Med Genet. 2023 Nov;60(11):1133-1141. doi: 10.1136/jmg-2023-109267. Epub 2023 Jul 17. J Med Genet. 2023. PMID: 37460201
A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.
Mulder MP, Witting K, Berlin I, Pruneda JN, Wu KP, Chang JG, Merkx R, Bialas J, Groettrup M, Vertegaal AC, Schulman BA, Komander D, Neefjes J, El Oualid F, Ovaa H. Mulder MP, et al. Nat Chem Biol. 2016 Jul;12(7):523-30. doi: 10.1038/nchembio.2084. Epub 2016 May 16. Nat Chem Biol. 2016. PMID: 27182664 Free PMC article.
SUMO targets the APC/C to regulate transition from metaphase to anaphase.
Eifler K, Cuijpers SAG, Willemstein E, Raaijmakers JA, El Atmioui D, Ovaa H, Medema RH, Vertegaal ACO. Eifler K, et al. Among authors: vertegaal aco. Nat Commun. 2018 Mar 16;9(1):1119. doi: 10.1038/s41467-018-03486-4. Nat Commun. 2018. PMID: 29549242 Free PMC article.
Probing ubiquitin and SUMO conjugation and deconjugation.
Ovaa H, Vertegaal ACO. Ovaa H, et al. Among authors: vertegaal aco. Biochem Soc Trans. 2018 Apr 17;46(2):423-436. doi: 10.1042/BST20170086. Epub 2018 Mar 27. Biochem Soc Trans. 2018. PMID: 29588386 Review.
101 results