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Discovery of Potent and Selective Antibody-Drug Conjugates with Eg5 Inhibitors through Linker and Payload Optimization.
Karpov AS, Nieto-Oberhuber CM, Abrams T, Beng-Louka E, Blanco E, Chamoin S, Chene P, Dacquignies I, Daniel D, Dillon MP, Doumampouom-Metoul L, Drosos N, Fedoseev P, Furegati M, Granda B, Grotzfeld RM, Hess Clark S, Joly E, Jones D, Lacaud-Baumlin M, Lagasse-Guerro S, Lorenzana EG, Mallet W, Martyniuk P, Marzinzik AL, Mesrouze Y, Nocito S, Oei Y, Perruccio F, Piizzi G, Richard E, Rudewicz PJ, Schindler P, Velay M, Venstrom K, Wang P, Zurini M, Lafrance M. Karpov AS, et al. Among authors: richard e. ACS Med Chem Lett. 2019 Dec 3;10(12):1674-1679. doi: 10.1021/acsmedchemlett.9b00468. eCollection 2019 Dec 12. ACS Med Chem Lett. 2019. PMID: 31857845 Free PMC article.
Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol.
Fu Y, Estoppey D, Roggo S, Pistorius D, Fuchs F, Studer C, Ibrahim AS, Aust T, Grandjean F, Mihalic M, Memmert K, Prindle V, Richard E, Riedl R, Schuierer S, Weber E, Hunziker J, Petersen F, Tao J, Hoepfner D. Fu Y, et al. Among authors: richard e. Nat Commun. 2020 Jul 7;11(1):3387. doi: 10.1038/s41467-020-17221-5. Nat Commun. 2020. PMID: 32636417 Free PMC article.
Promoter-Driven Overexpression in Chromobacterium vaccinii Facilitates Access to FR900359 and Yields Novel Low Abundance Analogs.
Pistorius D, Buntin K, Weber E, Richard E, Bouquet C, Wollbrett S, Regenass H, Peón V, Böhm M, Kessler R, Gempeler T, Haberkorn A, Wimmer L, Lanshoeft C, Davis J, Hainzl D, D'Alessio JA, Manchado E, Petersen F. Pistorius D, et al. Among authors: richard e. Chemistry. 2022 Feb 7;28(8):e202103888. doi: 10.1002/chem.202103888. Epub 2021 Dec 28. Chemistry. 2022. PMID: 34878202
Author Correction: Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol.
Fu Y, Estoppey D, Roggo S, Pistorius D, Fuchs F, Studer C, Ibrahim AS, Aust T, Grandjean F, Mihalic M, Memmert K, Prindle V, Richard E, Riedl R, Schuierer S, Weber E, Hunziker J, Petersen F, Tao J, Hoepfner D. Fu Y, et al. Among authors: richard e. Nat Commun. 2020 Jul 31;11(1):3913. doi: 10.1038/s41467-020-17748-7. Nat Commun. 2020. PMID: 32737318 Free PMC article.
Hyperactive delta isoform of PI3Kinase enables long distance regeneration of adult rat corticospinal tract.
Kristyna K, Zuzana P, Lydia K, Stepanka S, Bart N, Radovan H, Vit H, Lucia MU, Rostislav T, Jessica KC, van den Herik J, Joost V, Richard E, James FW, Pavla J. Kristyna K, et al. Among authors: richard e. Mol Ther. 2025 Jan 1:S1525-0016(24)00838-4. doi: 10.1016/j.ymthe.2024.12.040. Online ahead of print. Mol Ther. 2025. PMID: 39748509 Free article.
677 results