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Prediction Characteristics of Oral Absorption Simulation Software Evaluated Using Structurally Diverse Low-Solubility Drugs.
Matsumura N, Hayashi S, Akiyama Y, Ono A, Funaki S, Tamura N, Kimoto T, Jiko M, Haruna Y, Sarashina A, Ishida M, Nishiyama K, Fushimi M, Kojima Y, Yoneda K, Nakanishi M, Kim S, Fujita T, Sugano K. Matsumura N, et al. Among authors: akiyama y. J Pharm Sci. 2020 Mar;109(3):1403-1416. doi: 10.1016/j.xphs.2019.12.009. Epub 2019 Dec 18. J Pharm Sci. 2020. PMID: 31863733
Prediction Accuracy of Mechanism-Based Oral Absorption Model for Dogs.
Akiyama Y, Kimoto T, Mukumoto H, Miyake S, Ito S, Taniguchi T, Nomura Y, Matsumura N, Fujita T, Sugano K. Akiyama Y, et al. J Pharm Sci. 2019 Aug;108(8):2728-2736. doi: 10.1016/j.xphs.2019.03.015. Epub 2019 Mar 21. J Pharm Sci. 2019. PMID: 30905705
Prediction of Oral Drug Absorption in Rats from In Vitro Data.
Akiyama Y, Matsumura N, Ono A, Hayashi S, Funaki S, Tamura N, Kimoto T, Jiko M, Haruna Y, Sarashina A, Ishida M, Nishiyama K, Fushimi M, Kojima Y, Fujita T, Sugano K. Akiyama Y, et al. Pharm Res. 2023 Feb;40(2):359-373. doi: 10.1007/s11095-022-03173-6. Epub 2022 Feb 15. Pharm Res. 2023. PMID: 35169960
Harmonizing solubility measurement to lower inter-laboratory variance - progress of consortium of biopharmaceutical tools (CoBiTo) in Japan.
Ono A, Matsumura N, Kimoto T, Akiyama Y, Funaki S, Tamura N, Hayashi S, Kojima Y, Fushimi M, Sudaki H, Aihara R, Haruna Y, Jiko M, Iwasaki M, Fujita T, Sugano K. Ono A, et al. Among authors: akiyama y. ADMET DMPK. 2019 Aug 5;7(3):183-195. doi: 10.5599/admet.704. eCollection 2019. ADMET DMPK. 2019. PMID: 35350659 Free PMC article.
Pharmacological characterization of [trans-5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl]acetic acid monobenzenesulfonate (JTT-553), a novel acyl CoA:diacylglycerol transferase (DGAT) 1 inhibitor.
Tomimoto D, Okuma C, Ishii Y, Akiyama Y, Ohta T, Kakutani M, Ohkuma Y, Ogawa N. Tomimoto D, et al. Among authors: akiyama y. Biol Pharm Bull. 2015;38(2):263-9. doi: 10.1248/bpb.b14-00655. Biol Pharm Bull. 2015. PMID: 25747985 Free article.
Discovery of Novel NLRP3 Inflammasome Inhibitors Composed of an Oxazole Scaffold Bearing an Acylsulfamide.
Ohba Y, Adachi K, Furukawa T, Nishimaru T, Sakurai K, Masuo R, Inami T, Orita T, Akai S, Adachi T, Usui K, Hamada Y, Mori M, Kurimoto T, Wakashima T, Akiyama Y, Miyazaki S, Noji S. Ohba Y, et al. Among authors: akiyama y. ACS Med Chem Lett. 2023 Nov 10;14(12):1833-1838. doi: 10.1021/acsmedchemlett.3c00433. eCollection 2023 Dec 14. ACS Med Chem Lett. 2023. PMID: 38116417 Free PMC article.
2,053 results