Lomas DA - Search Results

1

C. elegans expressing D76N β₂-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis.

Faravelli G, Raimondi S, Marchese L, Partridge FA, Soria C, Mangione PP, Canetti D, Perni M, Aprile FA, Zorzoli I, Di Schiavi E, Lomas DA, Bellotti V, Sattelle DB, Giorgetti S. Faravelli G, et al. Among authors: lomas da. Sci Rep. 2019 Dec 27;9(1):19960. doi: 10.1038/s41598-019-56498-5. Sci Rep. 2019. PMID: 31882874 Free PMC article.

2

Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity.

Luheshi LM, Tartaglia GG, Brorsson AC, Pawar AP, Watson IE, Chiti F, Vendruscolo M, Lomas DA, Dobson CM, Crowther DC. Luheshi LM, et al. Among authors: lomas da. PLoS Biol. 2007 Oct 30;5(11):e290. doi: 10.1371/journal.pbio.0050290. PLoS Biol. 2007. PMID: 17973577 Free PMC article.

3

Alzheimer's disease: insights from Drosophila melanogaster models.

Moloney A, Sattelle DB, Lomas DA, Crowther DC. Moloney A, et al. Among authors: lomas da. Trends Biochem Sci. 2010 Apr;35(4):228-35. doi: 10.1016/j.tibs.2009.11.004. Epub 2009 Dec 25. Trends Biochem Sci. 2010. PMID: 20036556 Free PMC article. Review.

4

The TRiC/CCT chaperone is implicated in Alzheimer's disease based on patient GWAS and an RNAi screen in Aβ-expressing Caenorhabditis elegans.

Khabirova E, Moloney A, Marciniak SJ, Williams J, Lomas DA, Oliver SG, Favrin G, Sattelle DB, Crowther DC. Khabirova E, et al. Among authors: lomas da. PLoS One. 2014 Jul 31;9(7):e102985. doi: 10.1371/journal.pone.0102985. eCollection 2014. PLoS One. 2014. PMID: 25080104 Free PMC article.

5

An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes.

Partridge FA, Brown AE, Buckingham SD, Willis NJ, Wynne GM, Forman R, Else KJ, Morrison AA, Matthews JB, Russell AJ, Lomas DA, Sattelle DB. Partridge FA, et al. Among authors: lomas da. Int J Parasitol Drugs Drug Resist. 2018 Apr;8(1):8-21. doi: 10.1016/j.ijpddr.2017.11.004. Epub 2017 Dec 2. Int J Parasitol Drugs Drug Resist. 2018. PMID: 29223747 Free PMC article.

6

Calcium signalling in mammalian cell lines expressing wild type and mutant human α1-Antitrypsin.

Malintan NT, Buckingham SD, Lomas DA, Sattelle DB. Malintan NT, et al. Among authors: lomas da. Sci Rep. 2019 Nov 21;9(1):17293. doi: 10.1038/s41598-019-53535-1. Sci Rep. 2019. PMID: 31754242 Free PMC article.

7

Sequestration of the Abeta peptide prevents toxicity and promotes degradation in vivo.

Luheshi LM, Hoyer W, de Barros TP, van Dijk Härd I, Brorsson AC, Macao B, Persson C, Crowther DC, Lomas DA, Ståhl S, Dobson CM, Härd T. Luheshi LM, et al. Among authors: lomas da. PLoS Biol. 2010 Mar 16;8(3):e1000334. doi: 10.1371/journal.pbio.1000334. PLoS Biol. 2010. PMID: 20305716 Free PMC article.

8

Kumita JR, Helmfors L, Williams J, Luheshi LM, Menzer L, Dumoulin M, Lomas DA, Crowther DC, Dobson CM, Brorsson AC. Kumita JR, et al. Among authors: lomas da. FASEB J. 2012 Jan;26(1):192-202. doi: 10.1096/fj.11-185983. Epub 2011 Sep 29. FASEB J. 2012. PMID: 21965601 Free PMC article.

9

Expression in drosophila of tandem amyloid β peptides provides insights into links between aggregation and neurotoxicity.

Speretta E, Jahn TR, Tartaglia GG, Favrin G, Barros TP, Imarisio S, Lomas DA, Luheshi LM, Crowther DC, Dobson CM. Speretta E, et al. Among authors: lomas da. J Biol Chem. 2012 Jun 8;287(24):20748-54. doi: 10.1074/jbc.M112.350124. Epub 2012 Mar 29. J Biol Chem. 2012. PMID: 22461632 Free PMC article.

10

High-resolution ex vivo NMR spectroscopy of human Z α₁-antitrypsin.

Jagger AM, Waudby CA, Irving JA, Christodoulou J, Lomas DA. Jagger AM, et al. Among authors: lomas da. Nat Commun. 2020 Dec 11;11(1):6371. doi: 10.1038/s41467-020-20147-7. Nat Commun. 2020. PMID: 33311470 Free PMC article.

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