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Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway.
Shirakawa J, Tajima K, Okuyama T, Kyohara M, Togashi Y, De Jesus DF, Basile G, Kin T, Shapiro AMJ, Kulkarni RN, Terauchi Y. Shirakawa J, et al. Among authors: kulkarni rn. Diabetologia. 2020 Mar;63(3):577-587. doi: 10.1007/s00125-019-05071-w. Epub 2020 Jan 3. Diabetologia. 2020. PMID: 31897526 Free PMC article.
Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.
Ueki K, Okada T, Hu J, Liew CW, Assmann A, Dahlgren GM, Peters JL, Shackman JG, Zhang M, Artner I, Satin LS, Stein R, Holzenberger M, Kennedy RT, Kahn CR, Kulkarni RN. Ueki K, et al. Among authors: kulkarni rn. Nat Genet. 2006 May;38(5):583-8. doi: 10.1038/ng1787. Epub 2006 Apr 23. Nat Genet. 2006. PMID: 16642022
Growth factor signalling in the regulation of α-cell fate.
Kawamori D, Akiyama M, Hu J, Hambro B, Kulkarni RN. Kawamori D, et al. Among authors: kulkarni rn. Diabetes Obes Metab. 2011 Oct;13 Suppl 1:21-30. doi: 10.1111/j.1463-1326.2011.01442.x. Diabetes Obes Metab. 2011. PMID: 21824253 Review.
Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states.
El Ouaamari A, Kawamori D, Dirice E, Liew CW, Shadrach JL, Hu J, Katsuta H, Hollister-Lock J, Qian WJ, Wagers AJ, Kulkarni RN. El Ouaamari A, et al. Among authors: kulkarni rn. Cell Rep. 2013 Feb 21;3(2):401-10. doi: 10.1016/j.celrep.2013.01.007. Epub 2013 Jan 31. Cell Rep. 2013. PMID: 23375376 Free PMC article.
304 results