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Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway.
Shirakawa J, Tajima K, Okuyama T, Kyohara M, Togashi Y, De Jesus DF, Basile G, Kin T, Shapiro AMJ, Kulkarni RN, Terauchi Y. Shirakawa J, et al. Among authors: togashi y. Diabetologia. 2020 Mar;63(3):577-587. doi: 10.1007/s00125-019-05071-w. Epub 2020 Jan 3. Diabetologia. 2020. PMID: 31897526 Free PMC article.
Neither the presence of metabolic syndrome as defined by the IDF guideline nor an increased waist circumference increased the risk of microvascular or macrovascular complications in Japanese patients with type 2 diabetes.
Iwasaki T, Togashi Y, Ohshige K, Yoneda M, Fujita K, Nakajima A, Terauchi Y. Iwasaki T, et al. Among authors: togashi y. Diabetes Res Clin Pract. 2008 Mar;79(3):427-32. doi: 10.1016/j.diabres.2007.10.035. Epub 2008 Jan 22. Diabetes Res Clin Pract. 2008. PMID: 18207278
Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased β cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes.
Shirakawa J, Amo K, Ohminami H, Orime K, Togashi Y, Ito Y, Tajima K, Koganei M, Sasaki H, Takeda E, Terauchi Y. Shirakawa J, et al. Among authors: togashi y. J Biol Chem. 2011 Jul 22;286(29):25467-76. doi: 10.1074/jbc.M110.217216. Epub 2011 May 25. J Biol Chem. 2011. PMID: 21613229 Free PMC article.
[Retinal-blood barrier].
Togashi Y, Terauchi Y. Togashi Y, et al. Nihon Rinsho. 2010 Nov;68 Suppl 9:240-5. Nihon Rinsho. 2010. PMID: 21667482 Japanese. No abstract available.
391 results