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69 results

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In vivo liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects.
Osinski V, Bauknight DK, Dasa SSK, Harms MJ, Kroon T, Marshall MA, Garmey JC, Nguyen AT, Hartman J, Upadhye A, Srikakulapu P, Zhou A, O'Mahony G, Klibanov AL, Kelly KA, Boucher J, McNamara CA. Osinski V, et al. Among authors: harms mj. Theranostics. 2020 Jan 1;10(2):585-601. doi: 10.7150/thno.36572. eCollection 2020. Theranostics. 2020. PMID: 31903139 Free PMC article.
PPARγ and PPARα synergize to induce robust browning of white fat in vivo.
Kroon T, Harms M, Maurer S, Bonnet L, Alexandersson I, Lindblom A, Ahnmark A, Nilsson D, Gennemark P, O'Mahony G, Osinski V, McNamara C, Boucher J. Kroon T, et al. Mol Metab. 2020 Jun;36:100964. doi: 10.1016/j.molmet.2020.02.007. Epub 2020 Feb 18. Mol Metab. 2020. PMID: 32248079 Free PMC article.
Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce.
Li Q, Hagberg CE, Silva Cascales H, Lang S, Hyvönen MT, Salehzadeh F, Chen P, Alexandersson I, Terezaki E, Harms MJ, Kutschke M, Arifen N, Krämer N, Aouadi M, Knibbe C, Boucher J, Thorell A, Spalding KL. Li Q, et al. Among authors: harms mj. Nat Med. 2021 Nov;27(11):1941-1953. doi: 10.1038/s41591-021-01501-8. Epub 2021 Oct 4. Nat Med. 2021. PMID: 34608330
Lipoxins reduce obesity-induced adipose tissue inflammation in 3D-cultured human adipocytes and explant cultures.
Soták M, Rajan MR, Clark M, Harms M, Rani A, Kraft JD, Tandio D, Shen T, Borkowski K, Fiehn O, Newman JW, Quiding-Järbrink M, Biörserud C, Apelgren P, Staalesen T, Hagberg CE, Boucher J, Wallenius V, Lange S, Börgeson E. Soták M, et al. iScience. 2022 Jun 11;25(7):104602. doi: 10.1016/j.isci.2022.104602. eCollection 2022 Jul 15. iScience. 2022. PMID: 35789845 Free PMC article.
69 results