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Mechanism-of-Action Classification of Antibiotics by Global Transcriptome Profiling.
O'Rourke A, Beyhan S, Choi Y, Morales P, Chan AP, Espinoza JL, Dupont CL, Meyer KJ, Spoering A, Lewis K, Nierman WC, Nelson KE. O'Rourke A, et al. Among authors: spoering a. Antimicrob Agents Chemother. 2020 Feb 21;64(3):e01207-19. doi: 10.1128/AAC.01207-19. Print 2020 Feb 21. Antimicrob Agents Chemother. 2020. PMID: 31907190 Free PMC article.
Persister cells and tolerance to antimicrobials.
Keren I, Kaldalu N, Spoering A, Wang Y, Lewis K. Keren I, et al. Among authors: spoering a. FEMS Microbiol Lett. 2004 Jan 15;230(1):13-8. doi: 10.1016/S0378-1097(03)00856-5. FEMS Microbiol Lett. 2004. PMID: 14734160
Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2.
Gavrish E, Sit CS, Cao S, Kandror O, Spoering A, Peoples A, Ling L, Fetterman A, Hughes D, Bissell A, Torrey H, Akopian T, Mueller A, Epstein S, Goldberg A, Clardy J, Lewis K. Gavrish E, et al. Among authors: spoering a. Chem Biol. 2014 Apr 24;21(4):509-518. doi: 10.1016/j.chembiol.2014.01.014. Epub 2014 Mar 27. Chem Biol. 2014. PMID: 24684906 Free PMC article.
A new antibiotic kills pathogens without detectable resistance.
Ling LL, Schneider T, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A, Schäberle TF, Hughes DE, Epstein S, Jones M, Lazarides L, Steadman VA, Cohen DR, Felix CR, Fetterman KA, Millett WP, Nitti AG, Zullo AM, Chen C, Lewis K. Ling LL, et al. Among authors: spoering al. Nature. 2015 Jan 22;517(7535):455-9. doi: 10.1038/nature14098. Epub 2015 Jan 7. Nature. 2015. PMID: 25561178 Free PMC article.
Reducing the Bottleneck in Discovery of Novel Antibiotics.
Jones MB, Nierman WC, Shan Y, Frank BC, Spoering A, Ling L, Peoples A, Zullo A, Lewis K, Nelson KE. Jones MB, et al. Among authors: spoering a. Microb Ecol. 2017 Apr;73(3):658-667. doi: 10.1007/s00248-016-0889-3. Epub 2016 Nov 28. Microb Ecol. 2017. PMID: 27896376
Structural studies suggest aggregation as one of the modes of action for teixobactin.
Öster C, Walkowiak GP, Hughes DE, Spoering AL, Peoples AJ, Catherwood AC, Tod JA, Lloyd AJ, Herrmann T, Lewis K, Dowson CG, Lewandowski JR. Öster C, et al. Among authors: spoering al. Chem Sci. 2018 Sep 20;9(47):8850-8859. doi: 10.1039/c8sc03655a. eCollection 2018 Dec 21. Chem Sci. 2018. PMID: 30627403 Free PMC article.
Novel Antimicrobials from Uncultured Bacteria Acting against Mycobacterium tuberculosis.
Quigley J, Peoples A, Sarybaeva A, Hughes D, Ghiglieri M, Achorn C, Desrosiers A, Felix C, Liang L, Malveira S, Millett W, Nitti A, Tran B, Zullo A, Anklin C, Spoering A, Ling LL, Lewis K. Quigley J, et al. Among authors: spoering a. mBio. 2020 Aug 4;11(4):e01516-20. doi: 10.1128/mBio.01516-20. mBio. 2020. PMID: 32753498 Free PMC article.
21 results