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CFTR Therapeutics Normalize Cerebral Perfusion Deficits in Mouse Models of Heart Failure and Subarachnoid Hemorrhage.
Lidington D, Fares JC, Uhl FE, Dinh DD, Kroetsch JT, Sauvé M, Malik FA, Matthes F, Vanherle L, Adel A, Momen A, Zhang H, Aschar-Sobbi R, Foltz WD, Wan H, Sumiyoshi M, Macdonald RL, Husain M, Backx PH, Heximer SP, Meissner A, Bolz SS. Lidington D, et al. Among authors: heximer sp. JACC Basic Transl Sci. 2019 Nov 27;4(8):940-958. doi: 10.1016/j.jacbts.2019.07.004. eCollection 2019 Dec. JACC Basic Transl Sci. 2019. PMID: 31909302 Free PMC article.
Iron overload decreases CaV1.3-dependent L-type Ca2+ currents leading to bradycardia, altered electrical conduction, and atrial fibrillation.
Rose RA, Sellan M, Simpson JA, Izaddoustdar F, Cifelli C, Panama BK, Davis M, Zhao D, Markhani M, Murphy GG, Striessnig J, Liu PP, Heximer SP, Backx PH. Rose RA, et al. Among authors: heximer sp. Circ Arrhythm Electrophysiol. 2011 Oct;4(5):733-42. doi: 10.1161/CIRCEP.110.960401. Epub 2011 Jul 11. Circ Arrhythm Electrophysiol. 2011. PMID: 21747058 Free PMC article.
Metoprolol impairs resistance artery function in mice.
El Beheiry MH, Heximer SP, Voigtlaender-Bolz J, Mazer CD, Connelly KA, Wilson DF, Beattie WS, Tsui AK, Zhang H, Golam K, Hu T, Liu E, Lidington D, Bolz SS, Hare GM. El Beheiry MH, et al. Among authors: heximer sp. J Appl Physiol (1985). 2011 Oct;111(4):1125-33. doi: 10.1152/japplphysiol.01340.2010. Epub 2011 Jul 28. J Appl Physiol (1985). 2011. PMID: 21799135 Free PMC article.
Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia.
Tsui AK, Marsden PA, Mazer CD, Adamson SL, Henkelman RM, Ho JJ, Wilson DF, Heximer SP, Connelly KA, Bolz SS, Lidington D, El-Beheiry MH, Dattani ND, Chen KM, Hare GM. Tsui AK, et al. Among authors: heximer sp. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17544-9. doi: 10.1073/pnas.1114026108. Epub 2011 Oct 5. Proc Natl Acad Sci U S A. 2011. PMID: 21976486 Free PMC article.
72 results