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Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor.
Yamamoto K, Kakino A, Takeshita H, Hayashi N, Li L, Nakano A, Hanasaki-Yamamoto H, Fujita Y, Imaizumi Y, Toyama-Yokoyama S, Nakama C, Kawai T, Takeda M, Hongyo K, Oguro R, Maekawa Y, Itoh N, Takami Y, Onishi M, Takeya Y, Sugimoto K, Kamide K, Nakagami H, Ohishi M, Kurtz TW, Sawamura T, Rakugi H. Yamamoto K, et al. Among authors: takeya y. FASEB J. 2015 Aug;29(8):3342-56. doi: 10.1096/fj.15-271627. Epub 2015 Apr 15. FASEB J. 2015. PMID: 25877213
Angiotensin-converting enzyme 2 deficiency accelerates and angiotensin 1-7 restores age-related muscle weakness in mice.
Takeshita H, Yamamoto K, Nozato S, Takeda M, Fukada SI, Inagaki T, Tsuchimochi H, Shirai M, Nozato Y, Fujimoto T, Imaizumi Y, Yokoyama S, Nagasawa M, Hamano G, Hongyo K, Kawai T, Hanasaki-Yamamoto H, Takeda S, Takahashi T, Akasaka H, Itoh N, Takami Y, Takeya Y, Sugimoto K, Nakagami H, Rakugi H. Takeshita H, et al. Among authors: takeya y. J Cachexia Sarcopenia Muscle. 2018 Oct;9(5):975-986. doi: 10.1002/jcsm.12334. Epub 2018 Sep 11. J Cachexia Sarcopenia Muscle. 2018. PMID: 30207087 Free PMC article.
Pathophysiological significance of cylindromatosis in the vascular endothelium and macrophages for the initiation of age-related atherogenesis.
Imaizumi Y, Takami Y, Yamamoto K, Nagasawa M, Nozato Y, Nozato S, Takeshita H, Wang C, Yokoyama S, Hayashi H, Hongyo K, Akasaka H, Takeya Y, Sugimoto K, Nakagami H, Rakugi H. Imaizumi Y, et al. Among authors: takeya y. Biochem Biophys Res Commun. 2019 Jan 22;508(4):1168-1174. doi: 10.1016/j.bbrc.2018.12.025. Epub 2018 Dec 13. Biochem Biophys Res Commun. 2019. PMID: 30554661
Overexpression of Interleukin-15 exhibits improved glucose tolerance and promotes GLUT4 translocation via AMP-Activated protein kinase pathway in skeletal muscle.
Fujimoto T, Sugimoto K, Takahashi T, Yasunobe Y, Xie K, Tanaka M, Ohnishi Y, Yoshida S, Kurinami H, Akasaka H, Takami Y, Takeya Y, Yamamoto K, Rakugi H. Fujimoto T, et al. Among authors: takeya y. Biochem Biophys Res Commun. 2019 Feb 19;509(4):994-1000. doi: 10.1016/j.bbrc.2019.01.024. Epub 2019 Jan 14. Biochem Biophys Res Commun. 2019. PMID: 30654941
Angiotensin 1-7 alleviates aging-associated muscle weakness and bone loss, but is not associated with accelerated aging in ACE2-knockout mice.
Nozato S, Yamamoto K, Takeshita H, Nozato Y, Imaizumi Y, Fujimoto T, Yokoyama S, Nagasawa M, Takeda M, Hongyo K, Akasaka H, Takami Y, Takeya Y, Sugimoto K, Mogi M, Horiuchi M, Rakugi H. Nozato S, et al. Among authors: takeya y. Clin Sci (Lond). 2019 Sep 24;133(18):2005-2018. doi: 10.1042/CS20190573. Print 2019 Sep 30. Clin Sci (Lond). 2019. PMID: 31519791
A pressor dose of angiotensin II has no influence on the angiotensin-converting enzyme 2 and other molecules associated with SARS-CoV-2 infection in mice.
Wang Y, Takeshita H, Yamamoto K, Huang Y, Wang C, Nakajima T, Nozato Y, Fujimoto T, Yokoyama S, Hongyo K, Nakagami F, Akasaka H, Takami Y, Takeya Y, Sugimoto K, Rakugi H. Wang Y, et al. Among authors: takeya y. FASEB J. 2021 Mar;35(3):e21419. doi: 10.1096/fj.202100016R. FASEB J. 2021. PMID: 33566370 Free PMC article.
Double Deletion of Angiotensin II Type 2 and Mas Receptors Accelerates Aging-Related Muscle Weakness in Male Mice.
Takeshita H, Yamamoto K, Mogi M, Wang Y, Nozato Y, Fujimoto T, Yokoyama S, Hongyo K, Nakagami F, Akasaka H, Takami Y, Takeya Y, Sugimoto K, Horiuchi M, Rakugi H. Takeshita H, et al. Among authors: takeya y. J Am Heart Assoc. 2021 Jul 6;10(13):e021030. doi: 10.1161/JAHA.120.021030. Epub 2021 Jul 2. J Am Heart Assoc. 2021. PMID: 34212761 Free PMC article.
132 results